Searching for genes predisposing to complex diseases improved dramatically by genome-wide association studies (GWAS) 15 years ago. Before, it was similar a search needle in the haystack. Thirty ago, one had have first some evidence that at least “major gene” is influencing phenotype of interest. This came often from twin or segregation analysis done large pedigrees with Nowadays, these methods ...

HomeCirculation: Cardiovascular InterventionsVol. 14, No. 3Evolving Landscapes in Coronary Stents for Patients at High Bleeding Risk Free AccessEditorialPDF/EPUBAboutView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyRedditDiggEmail Jump toFree AccessEditorialPDF/EPUBEvolving Davide CapodannoMD, PhD CapodannoD...

Isoforms of cytochrome P-450 (CYP) involved in the metabolism of gallopamil enantiomers were identified by measuring the disappearance rate of parent drug from an incubation mixture with human liver microsomes and recombinant human CYPs. Mean (6 S.D.) intrinsic clearances (CLint) of R(1)and S(2)-gallopamil in human liver microsomes were 0.320 6 0.165 and 0.205 6 0.107 ml/min/mg protein, respect...

The latest trend in generating power for industrial and domestic purposes is the hybrid power generation using non-conventional energy sources. The non-conventional energy sources are the renewable sources that can be utilized again after every use and also whose supply is abundant in nature. This paper presents a new system configuration of the front-end rectifier stage for a hybrid wind/photo...

Global change frequently disrupts the connections among species, as well species and their environment, before most obvious impacts can be detected. Therefore, we need to develop a unified conceptual framework that allows us predict early ecological under changing environments. The concept of coupling, defined multiple ways in which biotic abiotic components ecosystems are orderly connected acr...

Phytophthora ramorum causes lethal canker diseases and extensive mortality in coast live oak (CLO) (Quercus agrifolia) and tanoak (Lithocarpus densiflorus). No practical controls are available for this disease in non-urban environments. Therefore, characterization of natural resistance is highly desirable. Variation in resistance to P. ramorum has been observed in CLO in both naturally infected...

In the present work, we studied the pharmacokinetics and metabolic disposition of [G-H]paclitaxel in a female patient with recurrent ovarian cancer and severe renal impairment (creatinine clearance: ;20 ml/min) due to chronic hypertension and prior cisplatin treatment. During six 3-weekly courses of paclitaxel at a dose level of 157.5 mg/m (viz. a 10% dose reduction), the renal function remaine...

In the glaciated mountains of Upper Indus Basin Pakistan, glacier- and snowmelt- based irrigation systems have been established over several centuries to secure water for cultivation. However, these are now facing challenges, being sensitive climate change thus exposed resulting extreme events such as glacial lake outburst floods (GLOFs) flash floods, also difficult terrain access paths, male o...

Deformable models are an attractive approach to recognizing objects which have considerable within-class variability such as handwritten characters. However, there are severe search problems associated with tting the models to data which could be reduced if a better starting point for the search were available. We show that by training a neural network to predict how a deformable model should b...

The information-deficit model is a common framework for explaining public attitudes towards new technologies, including renewable energy technology. This model assumes that public opposition to technology is based on a lack of quality information. The siting of facilities such as commercial wind farms frequently face opposition from residents of local communities, despite broad public support f...