Despite significant evidence of a role of hypoxia in cellular resistance to ionizing radiation-induced toxicity, the underlying molecular mechanisms remain unclear. This study focused on the influence of hypoxia on radiation-induced signals in TK6 human lymphoblastoid cells. Hypoxic (<10 ppm oxygen) and aerobic cells were exposed to equilethal doses of ionizing radiation, radiation dose ratio, ...

Racanisodamine, also known as 654-2, is an alkaloid extracted from the Solanaceae plant Scopolia tangutica in China. It a toxic mushroom-type M receptor antagonist. Racanisodamine used to treat diseases such organophosphorus poisoning, septic shock, pulmonary valve stenosis, and gastric ulcers. Additionally, can alleviate oxidative stress, inflammation, cell apoptosis induced by bleomycin-induc...

Abstract OBJECT The literature examining the optimal timing for initiating post-surgical therapy after glioblastoma surgery is brimming with inconsistencies, reports of both deleterious effects and benefits in delay at various time intervals. Moreover, there currently limited data pertinent to post-Stupp regimen era. Here, we use National Cancer Database (NCDB) explore this matter, a focus on p...

Widespread use of ionizing radiation has led to the realization of the danger associated with radiation exposure. Although studies in radiation countermeasures were initiated a half century ago, an effective therapy for a radiomitigator has not been identified. Ghrelin is a gastrointestinal hormone, and administration of ghrelin is protective in animal models of injuries including radiation com...

Introduction In order to discharge the patients receiving treatment with large radiation doses of 131I for thyroid cancer, it is necessary to measure and evaluate the external dose rates of these patients. The aim of the study was to assess a new method of external dose rate measurement, and to analyze the obtained results as a function of time. Materials and Methods In this study, a telescopic...

background: after radiation therapy (rt), some health hazards including dna damages may occur where melatonin can play a protective role due to free radical generation. on the other hand, serious accidental overexposures may occur during rt due to nuclear accidents which necessitate the need for study on exposure to high-dose radiations during treatments. objective: the aim of this study was to...

Background: Synthetic radio-protective agents like aminothiols are toxic and FDA approved agent amifostine is no exception. Some Ayurvedic herbs have shown radioprotective potential. This study was carried out to test and compare the radioprotective potential of Curcuma longa (CL) Tinospora cordifolia (TC), Zizyphus mauritiana (ZM) and Ocimum sanctum (OS) against 2Gy gamma irradiation ...

background: recently, there have been many studies on the harmful effects of radiation and the regulations on radiation safety have been toughened both at the in nation and abroad. this study aims to identify the perceptions and actions taken as to radiation safety, and the degree of knowledge related to radiation held by the radiologists working in large hospitals. materials and methods: the r...