CONTEXT We have previously shown that serum VEGF-D is elevated at baseline, correlates with kidney angiomyolipoma size at baseline and 12 months, and decreases with sirolimus treatment in adults with tuberous sclerosis complex (TSC). To further investigate the utility of serum VEGF-D for longer term monitoring of TSC kidney disease, we present VEGF-D level results with 24 month follow-up. OBJ...

In the phase 3 CASPIAN trial, 1L D+EP significantly improved OS vs EP and benefit was sustained after >3 years median follow-up (HR 0.71; 95% CI 0.60‒0.86; nominal p=0.0003). Here we assess clinical molecular characteristics of pts who experienced long-term survival in CASPIAN. 805 with ES-SCLC were randomised 1:1:1 to D+EP, D+T+EP or EP. post-hoc analyses, assessed survivors (LTS; n=94), defin...

Objective: This study is to investigate the effect of defibrase on deep vein thrombosis (DVT) following the surgical treatment for pelvic fracture. Methods: This study included 40 patients who received surgical treatment for pelvic fracture. Blood samples were collected at 24 h before surgery, and 24 h and 72 h after surgery. Plasma levels of endothelin (ET), thromboxane B2 (TXB2), and 6-Keto-P...

Six new minor saponins, together with known ginsenosides, were isolated from the leaves of Panax ginseng. The new saponins were named as ginsenoside-Rh5, -Rh6, -Rh7 -Rh8, -Rh9 and -Rg7, and their structures were elucidated on the basis of chemical and physicochemical evidence to be as follows: ginsenoside-Rh5: 3beta,6alpha,12beta,24zeta-tetrahydroxy-dammar-20(22),25-diene 6-O-beta-D-glucopyrano...

BACKGROUND Vitamin D insufficiency is associated with suboptimal health. The prevalence of vitamin D insufficiency may be rising, but population-based trends are uncertain. We sought to evaluate US population trends in vitamin D insufficiency. METHODS We compared serum 25-hydroxyvitamin D (25[OH]D) levels from the Third National Health and Nutrition Examination Survey (NHANES III), collected ...

Experiments were conducted to test the effect of temperature on oviposition in four species of the melanogaster group of Drosophila: D. ananassae, D. bipectinata, D. malerkotliana and D. biarmipes. In each species, two wild strains were used and eggs laid by females at three different temperatures (19 degrees C, 24 degrees C and 30 degrees C) were counted for four days at 24 h interval. It is e...

Regular consumption of vitamin D doses can improve heart function in patients with heart failure. The present study aimed to investigate the effect of vitamin D on the recovery process of neonates, infants, and children with Congenital Heart Disease (CHD) following reconstructive cardiac surgery. Materials and Methods: In this sing...

Background: Health benefits of vitamin D has been proved by a large number of studies, however, to the best of our knowledge there has been no study investigating the effect of mega dose of vitamin D on gestational diabetes mellitus (GDM). This study was the first to assess the effect of postpartum injection of mega dose of vitamin D on blood pressure (BP) in GDM. Methods: This is a randomized ...

6 The multiplier space and other spaces intrinsic to D theory 24 6.1 Multipliers . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 24 6.2 The weakly factored space D D and its dual . . . . . . . . . . . 25 6.3 The Corona Theorem . . . . . . . . . . . . . . . . . . . . . . . . 27 6.3.1 The ∂-equation in the Dirichlet Space . . . . . . . . . . . 28 6.3.2 Corona Theorems and Complete Nev...