Colon cancer is the third most common cancer and the third largest cause of cancer-related death. Fluorouracil (5-FU) is the front-line chemotherapeutic agent for colon cancer. However, its response rate is less than 60%, even in combination with other chemotherapeutic agents. The side effects of 5-FU also limit its application. Nanoparticles have been used to deliver 5-FU, to increase its effe...

Cathepsin K (CatK) is essential for osteoclast-mediated bone resorption. CatK expression is also detected in breast cancer cells that metastasize to bone. Here, the CatK inhibitor L-235 dosed in prevention (10, 30, and 100 mg/kg, p.o., b.i.d.) or treatment regimen (30 mg/kg) was compared with the bisphosphonate zoledronic acid (ZOL, 7.5 μg/kg/wk, s.c.) in the intratibial injection model of MDA-...

The system for distinguishing fl's from p's in the SPlZAR magnetic detector is described. The probabilities for misidentififying a fl as a 1-1 and a p as a n are determined experimentally.

In the course of studying the taxonomic diversity of osmo-tolerant yeasts in Tropical Southeast Asia, many yeast strains have been isolated from traditional fermented food, fruits, and other natural habitats. Among our isolates several new species were predicted by 26S rDNA D1/D2 nucleotide sequence analysis and a cation-tolerance test using LiCl (Nagatsuka et al., 2002, 2005). Citeromyces siam...

For some time it had been thought locally that the incidence of erysipeloid of Rosenbach among fish workers was much higher in Aberdeen than elsewhere. For this reason we began a systematic study of the disorder, and our findings over the period June 1, 1952, to September 30, 1953, are presented in this paper. Doctors generally are not familiar with the lesion known as erysipeloid. Because of i...

Researchers studied the use of a suite of synchronous communication tools in support of a Web-based, senior high school French course whose students were dispersed over the vast, sparsely populated province of Newfoundland and Labrador, Canada. The objective was to describe interaction according to four types: student-teacher, studentstudent, student-content, and student/teacher-tools. The inte...

Light was thrown on the nuclear aspects of Herndon’s georeactor. His thesis is that a power producing droplet of liquid uranium, possessing a radius of about 5 km, operated during the last 4.5 billions of years in the center of the Earth and producing 3–6 TW of thermal power. It could be shown that indeed initial criticality was possible due to the high U-235/U-238 enrichment of approximately 3...

BACKGROUND Hepatitis B, hepatitis C and HIV infections constitute serious healthcare problems worldwide. OBJECTIVES There are a limited number of studies regarding the prevalence of hepatitis B, hepatitis C and HIV infections among the drug addicts in Turkey; hence, the current study aimed to determine the frequency of these infections among 235 drug addicts treated in a drug addiction treatm...

We sought to determine whether genes of the renin-angiotensin-aldosterone system can predict the nonmodulating intermediate phenotype in essential hypertension. Aldosterone responses to angiotensin II were assessed in 298 subjects with hypertension. Subjects were genotyped at the angiotensinogen M235T, angiotensin-converting enzyme I/D, aldosterone synthase C-344 T, renin, angiotensin II type 1...