Epidemiological studies demonstrate an increase in age-related prevalence of dry eye disease (DED) and its higher occurrence women. In addition to alterations structures producing tear film, the reduction androgen levels other regulating hormones is important for DED development. The role estrogens progesterone regulation lacrimal meibomian gland activity still disputable. Additional factors de...

The blood bank at the New Haven Hospital was established in 1940. After two years of operation, a study of the incidence of transfusion reactions is undertaken. During this two-year period (from July 1, 1940, to July 1, 1942) 3388 transfusions of banked blood were given. Numerous studies of the incidence of reactions in stored whole blood transfusions have appeared in the literature. Reactions ...

Objective: To investigate the antineoplastic potential of a novel antiestrogen (AE) centchroman (CENT) using cell morphology, viability and cathepsin-D (Cath-D) gene expression as indices in MCF-7 human breast cancer cell line. Material and Methods: MCF-7 cells were incubated with CENT (1 μM, 10 μM) in the absence and presence of 17-β estradiol (E 2 , 10 nM) for 4 days. Investigations were carr...

A series of 320 amputations was analyzed with regard to wound healing complications and re-amputation rates. Among 111 AK amputations complications in wound healing were encountered in 14 per cent (15/111) of the cases, leading to re-amputation in 2 per cent (2/111). TK amputations were followed by wound healing problems in 30 per cent (20/66) of the cases with re-amputation in 20 per cent (13/...

Scanning electron microscopy was found to be of considerable use in evaluating the effects of various commonly used drugs, vehicles, and preservatives on the corneal surface. Of the preparations tested 0.3 per cent gentamicin caused many central cellular microvilli to stand up prominently. Moderate losses of peripheral microvilli, with mild superficial cellular desquamation was noted with 0.25 ...

Studies of the leucopenic effects of nitrous oxide were made in rodents, with and without surgical wounds. The animals were exposed to one of the following atmospheres: (1) air; (2) 25 per cent nitrous oxide; (3) 60 per cent (rats) or 40 per cent (mice) nitrous oxide; the oxygen percentage was maintained at 21 per cent in each case. A leucopenic effect and suppression of the normal leucocytosis...

The aim of the present study was to examine whether a putative relationship exists between the Class II division 2 craniofacial type and congenital anomalies of the dentition, such as missing teeth, peg-shaped laterals, transpositions, supernumerary teeth and canine impactions. Two hundred and sixty-seven untreated patients with Class II division 2 malocclusion were examined. The results show t...

ECLAMPSIA is a disease of theories and personal prejUd(li(S. 'l[his comimunication endleavours to present certaini facts emerging from a study of eighty-two conisecutive cases at the Jubilee Maternity Hospital in the ten-year period 1939-48. Ihese cases were treated mainlyr by the originial Stroganoff technique, but in the last two N7ears nmagniesiumii sulphate, so(liutm -ardenal, and other dru...

1. 10 per cent. atoxyl in blood incubated at 37 degrees C. for 1 hour gives rise to a solution that is much more than ten times as toxic as a 1 per cent. solution of atoxyl similarly incubated. 2. When the comparison is made after incubation for 3 hours instead of for 1 hour, the toxicity of the 10 per cent. solution is but slightly greater than ten times that of the 1 per cent., provided the r...

The present work aimed to evaluate, through ten different studies, the therapeutic efficacy of a new pour-on formulation, containing 1.5 per cent ivermectin +0.5 per cent abamectin, against parasites of cattle. Results obtained on trials against Rhipicephalus (Boophilus) microplus showed that the pour-on combination of 1.5 per cent ivermectin +0.5 per cent abamectin obtained superior efficacy i...