Complete androgen insensitivity syndrome or testicular feminization is the most common form of male pseudohermaphrodism, caused by a failure receptor binding. Patient with genotype 46 XY, has female morphotype well developed external sexual organs. We report case two young patients aged 23 and 21 TF discovered during exploration primary amenorrhea. A bilateral orchiectomy was performed institut...

Atrial natriuretic peptide (ANP)-C receptor activation has been shown to inhibit adenylyl cyclase (AC) activity as well as to stimulate phospholipase C (PLC) signaling pathways. The present studies were undertaken to investigate whether ANP-C receptor-mediated decreased cAMP levels contribute to the activation of PLC signaling. C-ANP(4-23) [des(Gln(18),Ser(19), Glu(20),Leu(21),Gly(22))ANP(4-23)...

Recently it was reported that l~«,25-dihydro\y vitamin O, [1,25iOH)zl),l inhibited cell growth in a cell Une derived from a metastasis from renal cell carcinoma. We have examined samples from 23 primary renal cell carcinomas for I,2S-(<)H)2D, receptor content, and compared it with the concentrations in autologous normal kidney tissue. Nineteen of 23 (83%) renal cell carcinomas had detectable (...

conclusions tlr8 rs3764880 and tlr9 rs148805533 polymorphisms may not be risk factors for susceptibility to tuberculosis in a sample of iranian population. larger studies are required to validate our findings. results the allelic and genotypic frequencies of the tlr8 rs3764880 did not differ significantly between ptb and the controls. no significant difference was found between the groups regar...

Recently it was reported that l~«,25-dihydro\y vitamin O, [1,25iOH)zl),l inhibited cell growth in a cell Une derived from a metastasis from renal cell carcinoma. We have examined samples from 23 primary renal cell carcinomas for I,2S-(<)H)2D, receptor content, and compared it with the concentrations in autologous normal kidney tissue. Nineteen of 23 (83%) renal cell carcinomas had detectable (...

Ligand-induced receptor dimerization has traditionally been viewed as the key event in transmembrane signalling by epidermal growth factor receptors (EGFRs). Here we show that the Caenorhabditis elegans EGFR orthologue LET-23 is constitutively dimeric, yet responds to its ligand LIN-3 without changing oligomerization state. SAXS and mutational analyses further reveal that the preformed dimer of...