A specific, acquired chromosomal abnormality (deletion 3p) has been found in at least one chromosome 3 in 100 percent of the metaphases in 12 of 12 cell lines cultured from human small-cell lung cancer tissue and in 2-day tumor culture specimens from three patients. Analysis of the shortest region of overlap shows the deletion to be 3p(14-23). This specific change was not seen in five of five l...

We have obtained Y-STR haplotypes in 12 loci (DYS19, DYS385, DYS389I, DYS389II, DYS390, DYS391, DYS392, DYS393, DYS437, DYS438 and DYS439) from 215 Buryat males. We have found that one haplotype (15-11,18-13-28-23-10-11-14-14-10-12) comprises more than 30% of Y chromosomes in this population while another haplotype (14-11,13-14-30-23-10-14-14-14-10-10) comprises additional 14% of chromosomes. T...

Three papers in the Journal this month examine the impact on service use of particular service developments and patient/illness characteristics. Williams et al (pp. 480–485) compared patterns of service use, including hospital admission rates, before and after the introduction of a triage admission system in one large innercity mental health organisation. Overall, little difference was found be...

Several papers in the BJPsych this month address issues arising from the overlap or comorbidity between mental and physical ill health. In a UK sample of individuals with affective disorders, Forty et al (pp. 465–472) found significantly increased rates of several medical illnesses among those with bipolar and unipolar disorder compared with controls. Among those with affective disorder, migrai...

While endocytosis can regulate morphogen distribution, its precise role in shaping these gradients is unclear. Even more enigmatic is the role of retromer, a complex that shuttles proteins between endosomes and the Golgi apparatus, in Wnt gradient formation. Here we report that DPY-23, the C. elegans mu subunit of the clathrin adaptor AP-2 that mediates the endocytosis of membrane proteins, reg...

Joint Implementation Supervisory Committee Tenth meeting Report Annex 3 Annex 3 SCHEDULE OF MEETINGS OF THE JOINT IMPLEMENTATION SUPERVISORY COMMITTEE IN 2008 Mo Tue Wed Thur Fri Sat Sun Mo Tue Wed Thur Fri Sat Sun Mo Tue Wed Thur Fri Sat Sun Mo Tue Wed Thur Fri Sat Sun Mo Tue 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17...