[2] B. Bhattacharya and R. Benkoczi. On computing the optimal bridge between two convex polygons. [7] H. Edelsbrunner. Computing the extreme distances between two convex polygons. Linear-time algorithms for visibility and shortest path problems inside triangulated simple polygons.

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Inward rectifier K+ channels are important in regulating membrane excitability in many cell types. The physiological functions of these channels are related to their unique inward rectification, which has been attributed to voltage-dependent block. Here, we show that inward rectification can also be induced by neutral and positively charged residues at site 224 in the internal vestibule of tetr...

Fetal bovine lung samples of 11 different gestational ages were assigned to a classical developmental stage based on histological morphology. Immunohistochemistry was used to characterize the morphology of forming airways, proliferation rate of airway epithelium and the presence of epithelial cell types (i.e. ciliated cells, club cells, neuroepithelial cells (NECs) and type II pneumocytes). Typ...

Streptomyces coelicolor RppA (Sc-RppA), a bacterial type III polyketide synthase, utilizes malonyl-CoA as both starter and extender unit substrate to form 1,3,6,8-tetrahydroxynaphthalene (THN) (therefore RppA is also known as THN synthase (THNS)). The significance of the active site Tyr(224) for substrate specificity has been established previously, and its aromatic ring is believed to be essen...

La Libye post-Kadhafi constitue un terreau opportun de reconfiguration géopolitique des migrations. Les pratiques et les dynamiques d’acteurs liées aux migrations s’inscrivent avant tout dans une continuité avec celles l’ère Kadhafi. La reconfiguration est le résultat processus d’adaptation acteurs, lié au contexte politique s...

This paper reports the results of an on-going research project at Cranfield University in collaboration with a leading consultant company. A major objective of the research to develop a new generation process planning system using the latest tools and technologies, and to fully comply with the international standard for exchange of product data (STEP) Application Protocol 224 (AP224) for proces...

An extensive investigation has been carried out on the compressive mechanical behaviour of type 224-carbon steel (0.18 wt % C, 1.21 wt % Mn) over the temperature range -110°C to +300°C and strain-rate 10" to 5000s", making possible the determination of the thermal sensitivity of this material. In several tests, a thermocouple was mounted inside each small cylindrical specimen to observe any tem...

Déjà d’ordinaire chevilles ouvrières des hôpitaux français, les internes ont largement été mobilisés pour faire face à la crise sanitaire de Covid-19. Parce qu’à fois encore en formation mais déjà jeunes médecins, leur regard sur transformations du système soin général, particulier, présente ainsi u...

GRASP65 phosphorylation during mitosis and dephosphorylation after mitosis are required for Golgi disassembly and reassembly during the cell cycle. At least eight phosphorylation sites on GRASP65 have been identified, but whether they are modified in a coordinated fashion during mitosis is so far unknown. In this study, we raised phospho-specific antibodies that recognize phosphorylated T220/T2...