نتایج جستجو برای: 218

تعداد نتایج: 7562  

2002
Jeffrey B. Dahmus

The mei-218 gene product is required for both meiotic crossing over and for the production of recombination nodules, suggesting that these organelles are required for meiotic exchange. In this study the null phenotype of mei-218 was defined through the analysis of three preexisting and five new alleles. Consistent with previous studies, in homozygous mi-218 mutants meiotic crossing over is redu...

Journal: :International Journal of Molecular Medicine 2016

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1994
W Huang R L Erikson

A variety of extracellular signals lead to the phosphorylation and activation of mitogen-activated protein kinases (MAP kinases). An activator of MAP kinases, Mek1, phosphorylates MAP kinases at threonine and tyrosine residues and is itself phosphorylated at serine-218 and -222 by the protooncogene product Raf-1. By introducing negatively charged residues that may mimic the effect of phosphoryl...

Journal: :Journal of the American College of Cardiology 2020

Journal: :Zeszyty Prawnicze Biura Analiz Sejmowych 2022

2011
Rozbeh Jafari Birgitta E Sundström Patrik Holm

BACKGROUND Optimization of conditions during recombinant protein production for improved yield is a major goal for protein scientists. Typically this is achieved by changing single crucial factor settings one at a time while other factors are kept fixed through trial-and-error experimentation. This approach may introduce larger bias and fail to identify interactions between the factors resultin...

Journal: :Blood 1991
R Amakawa S Fukuhara H Ohno F Matsuyama I Kato S Tanabe P Sideras T R Mizuta T Honjo M Okuma

In three lymphoma cell lines carrying t(14;18), named FL-18, FL-218, and FL-318, the genomic organization of IgH gene was compared with the expression of bcl-2 gene; the t(14;18) of the FL-18 cells occurred downstream from the major breakpoint cluster region (mbr) of a bcl-2 gene, and that of the FL-218 and FL-318 cells within the mbr. The FL-318 expressed the normal-sized bcl-2 transcript of 8...

2017
Hui Liu Nan Liu Yingduan Cheng Weilin Jin Pengxing Zhang Xin Wang Hongwei Yang Xiaoshan Xu Zhen Wang Yanyang Tu

In cancer, glycolysis driving enzymes and their regulating microRNAs are one of the key focus of oncology research lately. The glycolytic enzyme hexokinase 2 (HK2) is crucial for the Warburg effect in human glioma, the most common malignant brain tumor. In the present study, we studied the tumorigenic role of HK2 in glioma, and clarified the mechanism of miR-218 induced HK2 regulation in glioma...

Journal: :Stroke 2001
H Schmidt F Fazekas G M Kostner C M van Duijn R Schmidt

BACKGROUND AND PURPOSE Microangiopathy-related cerebral damage (MARCD) is a common finding in the elderly. It may lead to cognitive impairment and gait disturbances. Arterial hypertension and age are the most important risk factors. We assessed the association between MARCD and sequence alterations in the promoter region of the angiotensinogen (AGT) gene. METHODS We studied 410 randomly selec...

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