Experience with anidulafungin against Candida krusei is limited. Immunosuppressed mice were injected with 1.3 x 10(7) to 1.5 x 10(7) CFU of C. krusei. Animals were treated with saline, 40 mg/kg fluconazole, 1 mg/kg amphotericin B, or 10 and 20 mg/kg anidulafungin for 5 days. Anidulafungin improved survival and significantly reduced the number of CFU/g in kidneys and serum beta-glucan levels.

Objective: The present study was designed to investigate the putative antidepressant effects of crocin and crocetin, two major active ingredients of Crocus sativus L. (saffron) using mice in two different regimens of acute and sub-acute administration. Material and Methods: In acute treatment, antidepressant-like activities of crocin and crocetin (10, 20 and 40 mg/kg, i.p.) were evaluated using...

this experiment aimed to investigate the effect of (zero, 20, 40 and 60 mg/kg atriplex forage) malva sylvestris on digestibility and microbial fermentation of atriplex in one-humped camel. fermentation parameters by gas production technique and in vitro digestibility by two-stage digestion were measured by two years old female fistulated camels. addition 40 and 60 mg/kg malva sylvestris increas...

We investigated the effects of a wheat-based diet (WBD) supplemented with different levels of zinc on the performance, intestinal viscosity, immune system and lipid peroxidation of broiler chickens. A total of 240 Ross 308 day-old male broiler chicks were weighed and assigned to six dietary treatments with four replicates (floor pens) of ten birds per pen. Dietary treatments consisted of a WBD ...

Three groups of eight gilts weighing 20, 40, or 60 kg were fitted with indwelling venous catheters to determine daily integrated circulating levels (DICL, serum concentration above baseline x time) of insulin, growth hormone (GH), glucagon, glucose, urea, and nonesterified fatty acids (NEFA) in response to acute challenge with porcine pituitary GH (pGH). Pigs were fed a common diet containing 1...

Background and objectives: Long-term exposure to opiates induces tolerance to the analgesic effect. The chronic use of opioids in glia cells produces pro-inflammatory mediators such as Tissue Necrosis Factor α and interleukins. Regarding the reports on Ocimum basilicum (Family: Lamiaceae) which has antioxidant and anti-inflammatory effects, it is probable that it could...

ryanodine receptor abnormalities has implicated in the generation and maintenance of seizure. dantrolene, a selective ryanodine receptor antagonist, may be a potential drug for the prevention of seizure. therefore, we aimed to clarify the protective effects of dantrolene against pentylenetetrazole seizure in mice. male albino mice were received an intra-peritoneal injection of pentylenetetrazol...

BACKGROUND/AIMS Acidic saline injections produce mechanical hyperresponsiveness in male Sprague-Dawley rats. We investigated the effect of milnacipran in conjunction with tramadol on the pain threshold in an acidic saline animal model of pain. METHODS The left gastrocnemius muscle of 20 male rats was injected with 100 microL of saline at pH 4.0 under brief isoflurane anesthesia on days 0 and ...