In recent years, the linear economic model and global warming have shown that it is necessary to move toward a circular model. this scenario, recycling of waste electrical electronic equipment (WEEE) with green processes one pending tasks; thus, in present review, advances solid–liquid liquid–liquid extraction processes, among most important for recovery metals from ores or WEEE, solvents such ...

The hexosamine pathway has been implicated in the pathogenesis of diabetic complications. We determined first that hyperglycemia induced a decrease in glyceraldehyde-3-phosphate dehydrogenase activity in bovine aortic endothelial cells via increased production of mitochondrial superoxide and a concomitant 2.4-fold increase in hexosamine pathway activity. Both decreased glyceraldehyde-3-phosphat...

Oxidation of mitochondrial fatty acids (FA) results in the generation of reactive oxygen species (ROS) which have been postulated to play a key role in the initiation and progression of prostate cancer (PC). We previously reported that androgens increase FA uptake into PC cells. We thus examined if androgens that are known to induce ROS generation regulate FA oxidation in PC cells. The effects ...

UK-2A is a potent antifungal antibiotic and its structure is highly similar to that of antimycin A3 (AA). UK-2A and AA inhibit mitochondrial electron transport at complex III. C9-UK-2A, which has been prepared to improve the duration of the antifungal activity of UK-2A, shows durable fungicidal activities against various species of fungi and induces both membrane injury and the generation of ce...

Addition of NADP(+) to thylakoid membranes or isolated photosystem I (PSI) submembrane fractions quenched chlorophyll fluorescence by up to 40% at low or room temperature. This quenching was reversed by NADPH. Similar quenching was also observed with the addition of heparin or thenoyltrifluoroacetone (TTFA), inhibitors that bind ferredoxin:NADP(+) reductase (FNR) and prevent reduction of NADP(+...

The p53 system is highly stress sensitive and integrates diverse intracellular signals in a complex and poorly defined manner. We report on the high dependence of stress-induced p53 activation on mitochondrial activity. Down-regulation of mitochondrial transmembrane potential (MTMP) by inhibitors of electron transport (rotenone, thenoyltrifluoroacetone (TTFA)) and adenosine triphosphate (ATP) s...

Since the experiments of KEARNEY 1 it has been known that both particle-bound and soluble succinate dehydrogenase can be activated by its substrate succinate and by competitive inhibitors such as fumarate, malonate and phosphate. Binding at the active centre apparently brings the enzyme in an active conformation. GUTMAN et al. 2) 3 have recently reported that NADH is as effective as succinate i...

In cerebral microvascular endothelial cells (CMVEC) of newborn pigs, glutamate at excitotoxic concentrations (mM) causes apoptosis mediated by reactive oxygen species (ROS). Carbon monoxide (CO) produced by CMVEC or delivered by a CO-releasing molecule, CORM-A1, has antioxidant properties. We tested the hypothesis that CORM-A1 prevents cerebrovascular endothelial barrier dysfunction caused by g...

PURPOSE There is growing evidence that oxidative stress contributes to the progression of primary open-angle glaucoma (POAG), a leading cause of irreversible blindness worldwide. The authors provide evidence that mitochondrial dysfunction is a possible mechanism for the loss of trabecular meshwork (TM) cells in persons with POAG. METHODS TM from patients with POAG (GTM) and age-matched subjec...

A bis-β-diketone, bis(4,4,4-trifluoro-1,3-dioxobutyl)(2,2'-bithienyl) (BTT), which can be looked upon as coupling of two mono-β-diketones (2-thenoyltrifluoroacetone, TTA) at the 5,5'-position of thiophene ring, has been designed for exploring the advantages of binuclear helical structure in sensitizing the lanthanide NIR luminescence. The Yb(iii) ion was selected as the luminescent center, and ...