Abstract Background Lactones are important compounds in the field of medicine, material and chemical industry. One promising accesses to these flexible scaffolds is NAD(P) + -dependent alcohol dehydrogenases-catalyzed oxidative lactonization diols, which relies on construction an efficient regeneration system. Results In this study, a novel system combining horse liver dehydrogenase (HLADH) wit...

Chain-folded lamellar crystalline complexes of amylose with aliphatic diols were prepared and characterized by transmission electron microscopy as well X-ray diffraction. Four allomorphs identified, depending on the complexing diol crystallization conditions, that consisted orthorhombic lattices antiparallel 6- or 7-fold single helices. Straight-chain n-diols (ethane-1,2-diol, butane-1,4-diol, ...

[reaction: see text] The diastereoselective alkylation of glycolate oxazolidinones has been demonstrated as a method for the enantioselective preparation of alpha-alkoxy carboxylic acid derivatives and selectively protected 1,2-diols. Various protecting groups on the glycolate hydroxyl and multiple substitution patterns on allylic iodides are tolerated in the alkylation. Yields for the alkylati...

Four-membered ring [PhP(Se)(μ-Se)]2 (Woollins' reagent, WR) reacts with disodium alkenyl-diols followed by in situ ring-closure reaction with appropriate dibromoalkanes affording a series of unusual nine- to fifteen-membered organoselenophosphorus macrocycles bearing the O-P-Se-Cn-Se-P-O or O-P-Se-Cn-O-P-Se linkage.

Design and synthesis of chiral phosphines have played a significant role in the development of transition metal catalyzed asymmetric reactions.1 Many excellent chiral bidentate phosphines such as DIPAMP,2 DIOP,3 Chiraphos,4 and BINAP5 have been developed for a variety of catalytic reactions. Recent additions to this family of ligands include the Duphos and BPE species of Burk and co-workers.6 T...