نتایج جستجو برای: 2 pyridone
تعداد نتایج: 2525421 فیلتر نتایج به سال:
the stacking mechanism of the 1h-4h proton transfer in 4-pyridone, 4-pyridinthione and p-aminopyridineare constructed. for quantitative description of this process by means of the quamtumchemicalmethod density functional theory (dft) the activation energy (
N-Oxidation of 1,4-dihydro-2,6-dimethyl-1- phenyliminopyridine (7) with several peracids was attempted. The main compound obtained was l-phenyl- 2,6-dimethyl-4-pyridone (8), instead of the expected N-oxide (2). The reaction of phenylhydroxylamine with dimthylrnethoxypyroxonium perchlorate, however, successfully gave the N-oxide (3), which belongs to a class of nitrones in which the diazomet...
N-methyl-2-pyridone-5-carboxamide (2PY, a major metabolite of nicotinamide, NAM) was recently identified as a uremic toxin. Recent interventional trials using NAM to treat high levels of phosphorus in end-stage renal disease have highlighted new potential uremic toxicities of 2PY. In the context of uremia, the accumulation of 2PY could be harmful-perhaps by inhibiting poly (ADP-ribose) polymera...
Tris(2-pyridonyl)methanes may be synthesized via the reactions of the respective 2-pyridone with CHX3 (X = Cl, Br) and K2CO3 in the presence of [Bu(n)4N]Br, followed by acid-catalyzed isomerization with camphorsulfonic acid. These compounds provide access to a new class of alkyl ligands that feature oxygen donors and are capable of forming metallacarbatranes and a monovalent thallium alkyl comp...
This study evaluated the in vitro activity of A-86719.1, a novel 2-pyridone antimicrobial agent. The drug inhibited all tested members of the family Enterobacteriaceae at < or = 0.5 microgram/ml and all tested Pseudomonas aeruginosa, Burkholderia (Pseudomonas) cepacia, and Xanthomonas maltophilia strains at < or = 2 micrograms/ml. All but two strains of gram-positive bacteria were inhibited by ...
A series of previously unavailable derivatives of 2-alkyland 2-benzylderivatives of oxazolo[3,2-a]pyridines III were obtained via tandem ring opening and ring closure from stable mesoionic 3-acyloxazolo[3,2-a]pyridinium-2-olates I. The key intermediates of this tandem transformation are N-(b-oxoethyl)pyridones-2 II obtained by Dakin-West acylation of (pyridone-2-yl-1)acetic acid. An example of ...
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