Two novel separation methods have been presented for the concurrent assessment of flumethasone pivalate (FP) and clioquinol (CL) in their combinations ear drop formulations or presence phenoxyethanol preservative (PEP) cream formulations. The first method is an innovative thin-layer chromatographic (TLC) method. optimal was accomplished via silica gel aluminum plates F254, with a mixture benzen...

A stability-indicating RP-HPLC method has been developed and validated for the simultaneous determination of phenoxyethanol (PE), methylparaben (MP), propylparaben (PP), mometasone furoate (MF), and tazarotene (TA) in topical pharmaceutical dosage formulation. The desired chromatographic separation was achieved on the Waters X-Bridge™ C18 (50×4.6mm, 3.5μ) column using gradient elution at 256 nm...

BACKGROUND Glycol ethers are present in a wide range of occupational and domestic products. Animal studies have suggested that some of them may affect ovarian function. OBJECTIVE We examined the relation between women's exposure to glycol ethers and time to pregnancy. METHODS We used chromatography coupled to mass spectrometry to measure eight glycol ether metabolites in urine samples from ...

Acetic acid is a traditional antiseptic agent that has been used for more than 6000 years. The main goal of this study was to demonstrate the suitability of Suprathel (PolyMedics Innovations GmbH, Denkendorf, Germany) in combination with various antiseptic agents to create an "antiseptic-matrix" especially designed for problematic microorganisms such as Proteus vulgaris, Acinetobacter baumannii...

AIMS To develop a rapid method for the assessment of biocidal activity directed towards intact biofilms. METHODS AND RESULTS Escherichia coli and Staphylococcus epidermidis were cultured for up to 48 h within 96-well microtitre plates. The planktonic phase was removed and the wells rinsed. Residual biofilms were exposed to various concentrations of chloroxylenol, peracetic acid, polyhexamethy...

BACKGROUND Glycol ethers (GE) are widely used organic solvents. Despite the potential neurotoxicity of several families of organic solvents, little is known about the impact of GE on the neurodevelopment of infants and children. OBJECTIVES We investigated the relation between urinary concentrations of GE metabolites in pregnant women and neurocognitive abilities in their 6-year-old children i...

BACKGROUND Simultaneous or sequential exposure to multiple environmental stressors can affect chemical toxicity. Cumulative risk assessments consider multiple stressors but it is impractical to test every chemical combination to which people are exposed. New methods are needed to prioritize chemical combinations based on their prevalence and possible health impacts. OBJECTIVES We introduce an...

The cases of contact dermatitis due to using polyvinyl alcohol (PVA) towel containing isothiazolinone preservatives have been reported in Japan and we had investigated the concentrations of isothiazolinones and the removal of these preservatives from PVA towels by washing before initial use in the previous study conducted from 2011 to 2012. However, the clinical information regarding contact de...