We have previously reported the anti-neoplastic properties of ~-methylthio-4-amino-5-hydroxymethylpyrimidine (methioprim) and of other related pyrimidines with modification of the 2alkylthio substituent (2). These compounds were initially chosen for study following the observations of Guthrie et a/. that collateral sensitivity for methioprim was demonstrable in amethopterin-resistant strains of...

The maintenance of excitatory and inhibitory balance in the brain is essential for its function. Here we find that the developmental axon guidance receptor Roundabout 2 (Robo2) is critical for the maintenance of inhibitory synapses in the adult ventral tegmental area (VTA), a brain region important for the production of the neurotransmitter dopamine. Following selective genetic inactivation of ...

greenhouse and laboratory studies were conducted to examine the allelopathic effects of water extracts of pigweed (amaranthus retroflexu l.) leaf, stem, root and flower at different growth stages on canola seed germination and seedling growth. water extracts of leaf, stem, root and flower as individually, binary, ternary and quadri mixtures at 0, 50 and 100% concentrations were made and their e...

a simple and efficient one-pot three-component synthesis of the biologically important spirooxindole-4h-pyrans was carried out by the reaction of isatin, activated methylene reagents, and 4-hydroxycoumarin in aqueous medium. sba-pr-nh2 was found to be an efficient heterogeneous nanoporous solid basic catalyst (pore size of 6 nm) which can be easily handled and removed from the reaction mixture ...

background and objective: although there are reports in the literature on the antimicrobial effects of green tea, the effect of black tea, the most common beverage in iran, on growth of bacteria, such as streptococcus pyogenes, has not been studied extensively. this study was undertaken to determine the inhibitory effect of black tea on the growth of streptococcus pyogenes in vitro and compare ...

results in total, 73 isolates were collected and diagnosed as s. pneumoniae. isolates were susceptible to ofloxacin 95.9%, vancomycin 93%, penicillin 78%, trimethoprim-sulfamethoxazole 61.6%, ceftriaxone 53.5%, meropenem 52%, cefotaxime 46.5%, and erythromycin 8.2%. of the 15 prsp isolates, the pbp2b gene was identified in 12 (80%). in 1 penicillin-intermediate s. pneumoniae isolate the pbp2b w...