and Applied Analysis 3 Conversely, if the pair of functions α and β satisfy the conditions 1 – 4 , then there exists a unique u ∈ E1 such that u λ α− λ , β λ for each λ ∈ 0, 1 , 9 . The fuzzy number u corresponding to the pair of functions α and β is defined by u : R → 0, 1 , u x sup{λ : α x ≤ λ ≤ β x }, 5 . A sequence u uk of fuzzy numbers is a function u from the set N, the set of all positiv...

Ca 2+-transporting ATPase of sarcoplasmic reticulum couples ATP hydrolysis with ion transport. Phosphorylation of the cytosolic region of the calcium-bound conformation (E1) of the protein leads to drastic conformational rearrangements of the transmembrane helices and the release of Ca 2+. The resulting calcium-free conformation (E2) is less stable than the E1 form. We compare the changes in va...

Equid herpesvirus 2 (EHV-2), in common with other members of the subfamily Gammaherpesvirinae, encodes homologues of cellular seven-transmembrane receptors (7TMR), namely open reading frames (ORFs) E1, 74 and E6, which each show some similarity to cellular chemokine receptors. Whereas ORF74 and E6 are members of gammaherpesvirus-conserved 7TMR gene families, E1 is currently unique to EHV-2. To ...

Early artificial intelligence programming languages that incorporated search and backtracking facilities did not limit backtracking to previous computations when a portion of a search failed [1]. This had two unpleasant consequences: (1) the amount of data that had to be retained to allow backtracking limited the problems that could be handled, and (2) unexpected failure could cause backtrackin...

Resolvins, an endogenous lipid mediator derived from eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA) of fish oil, has been reported to have anti-inflammatory and antitumor effect in various pathogenic processes. However, there are no studies about the effects of resolvin D1 and E1 on concanavalin A-induced hepatitis. Hence, the present study is to illustrate whether resolvin D1 and E1...

The papillomavirus E1 helicase, with the help of E2, assembles at the viral origin into a double hexamer that orchestrates replication of the viral genome. The N-terminal region (NTR) of E1 is essential for DNA replication in vivo but dispensable in vitro, suggesting that it has a regulatory function. By deletion analysis, we identified a conserved region of the E1 NTR needed for efficient repl...

Replication of the double-stranded, circular human papillomavirus (HPV) genomes requires the viral DNA replicase E1. Here, we report an initial characterization of the E1 cistron of HPV type 16 (HPV-16), the most common oncogenic mucosal HPV type found in cervical and some head and neck cancers. The first step in HPV DNA replication is an initial burst of plasmid viral DNA amplification. Comple...

conclusions presence of cae in patients with cas increases its cardiovascular event rate. isolated cae is not a benign finding and mi can occur. risk factors of cae are similar to cas, but c/s is more associated with cae than cas. dm is seen in cae patients less than cas. results hypertension (htn), dyslipidemia (dlp), and male sex were matched in both groups without significant difference. cig...

The metabolic activities and tissue binding of estrone (E1) and estrone sulfate (E1S) on futile cycling were examined. Desulfation of E1S in the 9000g supernatant fraction (S9) of periportal (PP) and perivenous (PV) rat hepatocytes were of similar V (2.9 +/- 1.0 and 2.4 +/- 0.9 nmol/min/mg of S9 protein), K (30.4 +/- 8.3 and 34.8 +/- 6.6 microM), and desulfation intrinsic clearances (V/K of 77 ...