Niessen, C. Erik Hack, Willem T. Hermens, Freek W. A. Verheugt, Gert-Jan Wolbink J.C. Kaski, Xavier Garcia-Moll, Wim K. Lagrand, Cees A. Visser, Hans W. M. C-Reactive Protein as a Clinical Marker of Risk • Response ISSN: 1524-4539 Copyright © 2000 American Heart Association. All rights reserved. Print ISSN: 0009-7322. Online 72514 Circulation is published by the American Heart Association. 7272...

In this paper we propose a new semiparametric procedure for estimating multivariate models with conditioning variables. The semiparametric model is based on the parametric conditional copula of Patton (2005a) and nonparametric conditional marginals. To avoid the curse of dimensionality in the estimation of the latter, we propose a dimension reduction technique. The marginals are estimated using...

We consider a metric entropy capable of detecting deviations from symmetry that is suitable for both discrete and continuous processes. A test statistic is constructed from an integrated normed difference between nonparametric estimates of two density functions. The null distribution (symmetry) is obtained by resampling from an artificially lengthened series constructed from a rotation of the o...

Project results show that the international industrial networks in CEE are organized by MNCs and are limited in scope (mainly intra-firm). The weakest node for further industry upgrading via network alignment is a national network. There are big national differences in network alignment across CEECs. These differences reflect differences in the strategies of MNCs; the different roles of governm...

1 Introduction The current process of east-west European integration is a particularly striking example of the re-emergence of strong trade and, more generally, production linkages between two groups of economies which, albeit geographically close to each other, have had minimal trade and FDI links over a forty-year period. The rapid and deep liberalization of external relations after 1989 (acc...

Background: The Women’s Health Initiative (WHI) clinical trial of conjugated equine estrogens (CEEs), involving 10 739 postmenopausal women with hysterectomy, aged 50 to 79 years, was stopped early owing to lack of overall health benefit and increased risk of stroke. Because CEE is still prescribed for treatment of menopausal symptoms and prevention of osteoporosis, it is important to understan...

Metal-free transfer hydrogenation of polarized olefins (RR'C=CEE': R, R' = H or organyl, E, E' = CN or CO(2)Me) using amine borane adducts RR'NH-BH(3) (R = R' = H, AB; R = Me, R' = H, MAB; R = (t)Bu, R' = H, tBAB; R = R' = Me, DMAB) as hydrogen donors, were studied by means of in situ NMR spectroscopy. Deuterium kinetic isotope effects and the traced hydroboration intermediate revealed that the...

SUMMARY This paper explores growth and competitive advantage in CEE software firms; it looks at the role of strategic partnerships and industry (spillover) effects. The empirical analysis is based on survey data from 224 software firms from six CEE countries (Bulgaria, Czech R, Estonia, Serbia, Slovenia, Romania). The results of the descriptive analysis are interpreted from the perspective of t...

North-East Arctic cod is shared by Russia and Norway. Taking its multi-cohort structure into account, how would optimal management look like? How would non-cooperative exploitation limit the obtainable profits? To which extent could the strategic situation explain today’s over-harvesting? Simulation of a detailed bioeconomic model reveals that the mesh size should be significantly increased, re...

The 'watch dog' role of the media, the impact of migration processes, health care access for children in developing countries, mitigation of the effects of Global Warming are typical examples of governance issues – issues to be tackled at the base; issues to be solved by creating and implementing effective policy. students to pave the road for innovative policy developments in Europe and the wo...