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تعداد نتایج: 809 فیلتر نتایج به سال:
The main aim of this paper is to analyse and estimate the behaviour Spanish economic activity in next 12 months, by means a Real-Time Leading Economic Indicator (RT-LEI), based on Google Trends, real GDP. We apply methodologies fractional integration cointegration measure degree persistence examine long-term relationship. Finally, we carry out forecast using Machine Learning model an Artificial...
Mutations in the amyloid precursor protein (APP) and presenilin-1 and -2 genes (PS-1, -2) cause Alzheimer's disease (AD). Mice carrying both mutant genes (PS/APP) develop AD-like deposits composed of beta-amyloid (Abeta) at an early age. In this study, we have examined how Abeta deposition is associated with immune responses. Both fibrillar and nonfibrillar Abeta (diffuse) deposits were visible...
Loss of heterozygosity at particular chromosomal loci in the tumor cell, as evidenced by restriction fragment length polymorphism analysis, has been taken as a hallmark of the presence of tumor suppressor genes. Recent studies of breast carcinoma have suggested that such genes might be located on the short as well as on the long arm of chromosome 1. We report here that comparison of constitutio...
Myelodysplastic syndrome (MDS) is a clonal disorder of the pluripotent hematopoietic stem cells which is characterized by ineffective and dysplastic hematopoiesis. The pathogenesis of MDS is not well defined and it appears that multiple genetic changes are involved. Several studies have shown that certain chromosomal abnormalities may be influenced by environmental factors, while differences in...
The discretization of Cahn-Hilliard equation with obstacle potential leads to a block 2ˆ2 non-linear system, where the p1, 1q block has a non-linear and non-smooth term. Recently a globally convergent Newton Schur method was proposed for the non-linear Schur complement corresponding to this non-linear system. The solver may be seen as an inexact Uzawa method which has the falvour of an active s...
PURPOSE To define copy number alterations and gene expression signatures underlying pediatric high-grade glioma (HGG). PATIENTS AND METHODS We conducted a high-resolution analysis of genomic imbalances in 78 de novo pediatric HGGs, including seven diffuse intrinsic pontine gliomas, and 10 HGGs arising in children who received cranial irradiation for a previous cancer using single nucleotide p...
The highly unsaturated binuclear butadiene iron carbonyls (C(4)H(6))(2)Fe(2)(CO)(n) (n = 2, 1) have been examined using density functional theory. For (C(4)H(6))(2)Fe(2)(CO)(n) (n = 2, 1), both coaxial and perpendicular structures are found. The global minima of (C(4)H(6))(2)Fe(2)(CO)(n) (n = 2, 1) are the perpendicular structures 2Q-1 and 1Q-1, respectively, with 17- and 15-electron configurat...
Human C'1, a macromolecular complex composed of three subunits, is the zymogen for at least two distinct enzymes. Preparations of one subunit, C'1r, functioned as a protease which converted another subunit, C'1s, to C'1 esterase. The conversion of C'1s to C'1 esterase by C'1r was blocked by Liquoid, phenyl methylsulfonyl fluoride, and calcium ions, but not by soybean trypsin inhibitor, hirudin,...
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