Abstract A simple sublimation technology for the lutetium and ytterbium separation was proposed, which already at stage of preliminary experiments showed effectiveness: (a) completeness Yb resulted in short-term thermal annealing is least 98%, distilled product completely free from 177 Lu, no additional preparation repeated irradiation required ; (b) traditional ion-exchange chromatography can ...

Theranostics is an acronym, which exemplifies the togetherness of diagnostics and therapeutics in the individualized management of disease. The key to personalized medicine in cancer is to determine the molecular phenotypes of neoplasms, so that specific probes can be selected to target the tumor and its microenvironment. Molecular imaging and radionuclide therapy using a particular probe is ba...

Theranostic RIT in CRC Researchers from Memorial Sloan– Kettering Cancer Center (New York, NY) and the Massachusetts Institute of Technology (Cambridge, MA) reported on continuing small animal studies with curative theranostic pretargeted 177LuDOTAT-Bn radioimmunotherapy (PRIT) in GPA33-expressing colorectal cancer. Mice with established SW1222 subcutaneous xenografts underwent treatment with 1...

Introduction: Somatostatin receptors expressed on a wide range of human tumors, are potential targets for the peptide receptor radionuclide therapy (PRRT). In this study, 177Lu-[DOTA-DPhe1, Tyr3]octreotide (177Lu-DOTATOC) as an agent for PRRT was prepared and its biodistribution was studied in rats. Methods:The ...

Uptake and dose distributions in peritoneal LS174T colon tumor xenografts were compared for a humanized construct of the CC49 (HuCC49) high-affinity anti-TAG-72 monoclonal antibody and a construct with the CH2 region deleted (HuCC49DeltaCH2), both labeled with (177)Lu using a PA-DOTA bifunctional chelating agent and injected in the peritoneum. Tumors were resected and serially sectioned at 1 h,...