Retinoblastoma is a rare pediatric cancer that has served as a paradigm to investigate the mechanisms of tumorigenesis. In this issue of Genes & Development, Conkrite and colleagues (pp. 1734-1745) found high levels of the miR-17~92 and miR-106b-25 microRNAs in primary retinoblastomas and show that overexpression of miR-17~92 accelerates retinoblastoma development in mice by promoting prolifera...

We are presenting here an updated version of our predictive model of solvation parameters of solutes, based on a simplified molecular topology (J. Chem. Inf. Model, 2006, 46, 1723-1734). The learning experimental database of this model is presently larger than in our first version and includes more compounds with more than one functional group of the same type. This experimental database is als...

The family of Toll-like receptors plays an essential role in the induction of the immune response. These receptors sense the presence of microbial ligands and activate the nuclear factorB transcription factor. We review the key studies that led from the formulation of the concept of pattern recognition receptors to the characterization of Toll-like receptors, insisting on the important role pla...

Bamboo is one of the fastest growing plants and has mechanical properties similar to timber. The main reasons for popularity bamboo in construction can be attributed its low cost, local availability, adequacy simple, tools, skills fabrication. Application is, however, normally limited low-cost housing temporary structures due several factors including irregular shapes, hollow circular cross sec...

Nyeri muskuloskeletal menjadi masalah kesehatan utama yang menyerang para petani maupun profesi lainnya akibat beban fisik dan durasi kerja tinggi. Dengan keterbatasan modalitas terapi saat ini, Transcutaneous Electrical Nerve Stimulation (TENS) dapat potensial. Systematic review ini bertujuan untuk mengkaji efikasi TENS pada nyeri dengan penyebab non-spesifik di dua lokasi tubuh tersering, yai...

While IMAP4 supports a number of strong authentication mechanisms as described in RFC 1731, it lacks any mechanism that neither passes cleartext, reusable passwords across the network nor requires either a significant security infrastructure or that the mail server update a mail-system-wide user authentication file on each mail access. This specification provides a simple challenge-response aut...

Forecasting is one of the main topics in data mining or machine learning which forecasting, a group used, has label class target. Thus, many algorithms for solving forecasting problems are categorized as supervised with aim conducting training. In this case, things that were target playing role 'supervisor' who supervise training process achieving certain level accuracy precision. Time series m...