PURINERGIC RECEPTOR-MEDIATED RAPID DEPLETION OF NUCLEAR pAKT DEPENDS ON PH DOMAIN LEUCINE-RICH REPEAT PHOSPHATASE (PHLPP), CALCINEURIN, PP2A and PTEN PHOSPHATASES Oras Mistafa*, Aram Ghalali*, Sandeep Kadekar, Johan Högberg and Ulla Stenius * contributed equally Institute of Environmental Medicine, Karolinska Institutet, S-171 77 Stockholm, Sweden Running head: pAkt depletion by protein and lip...

FUSHUN YU,1,2 STEN GÖTHE,3 LILIAN WIKSTRÖM,3 DOUGLAS FORREST,4 BJÖRN VENNSTRÖM,3 AND LARS LARSSON1,2 1Noll Physiological Research Center and Department of Cellular and Molecular Physiology, Pennsylvania State University, University Park, Pennsylvania 16802-6900; 2Department of Clinical Neuroscience, Karolinska Institute/Karolinska Hospital, 171 76 Stockholm; 3Laboratory of Developmental Biology...

En 1939, une longue étude consacrée au Code de la famille paraît dans section doctrinale Gazette du Palais, sous plume professeur droit civil, Paul Esmein. Dans les « Généralités », l’auteur s’arrête sur principes inspirateurs des dispositions prises par le gouvernement Daladier en matière famille, démographie et natal...

1 Institute of Environmental Medicine, Karolinska Institutet, P.O. Box 210, SE-171 77 Stockholm, Sweden; E-Mails: [email protected] (M.F.); [email protected] (D.P.); [email protected] (M.T.) 2 Regional Cancer Center, Uppsala/Örebro and The National Board of Health and Welfare, SE-112 59 Stockholm, Sweden; E-Mail: [email protected] 3 Nordic Collaborating Centre for Classifi...

J. CARLESON, 1'2 P. ALSTERGREN, 2 A. APPELGREN, 2 B. APPELGREN, 2 S. KOPP, 2 G. R. SRINIVASAN, 4 E. THEODORSSON 4 and T. LUNDEBERG 1'3'* ~Department of Physiology and Pharmacology, Division of Physiology II, S-171 77, Stockholm, Sweden, 2Center for Clinical Oral Science, School of Dentistry, Karolinska Institutet, Box 4064, S-141 04, Huddinge, Sweden, 3Nociceptive Pain Unit, Department of Rehab...

This paper discusses If multi-agent learning is the answer, what is the question? [Y. Shoham, R. Powers, T. Grenager, If multiagent learning is the answer, what is the question? Artificial Intelligence 171 (7) (2007) 365–377, this issue] from the perspective of evolutionary game theory. We briefly discuss the concepts of evolutionary game theory, and examine the main conclusions from [Y. Shoham...

S ................................................................................................................................................................ 167 1. German .............................................................................................................................................................. 168 2. French ..................................................

Alors que le « nouvel esprit du capitalisme » était en France silencieux sur les inégalités entre femmes et hommes, depuis années 2000, l’exigence d’égalité semble avoir été cooptée par discours gestionnaire, notamment principe de mixité dans espaces décision métiers techniques. Mais comment expliquer l&...

AMA Hellerová V, Dolák F, Chloubová I, et al. COVID-19 pandemic through the eyes of general nurses in South Bohemian Region: a qualitative study. Family Medicine & Primary Care Review. 2023;25(2):165-171. doi:10.5114/fmpcr.2023.127675. APA Hellerová, V., Dolák, F., Chloubová, I., Bártlová, S., Tóthová, Kimmerová, J. (2023). Review, 25(2), 165-171. https://doi.org/10.5114/fmpcr.2023.127675 Chica...

The CREB-specific coactivator TORC2 (also known as CRTC2) upregulates gluconeogenic gene expression in the liver. Salt-inducible kinase (SIK) family enzymes inactivate TORC2 through phosphorylation and localize it in the cytoplasm. Ser(171) and Ser(275) were found to be phosphorylated in pancreatic beta-cells. Calcineurin (Cn) is proposed as the Ser(275) phosphatase, because its inhibitor cyclo...