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Smac mimetics are being developed as a new class of anticancer therapies. Because the single-agent activity of Smac mimetics is very limited, rational combinations represent a viable strategy for their clinical development. The combination of Smac mimetics with TNF-related apoptosis inducing ligand (TRAIL) may be particularly attractive because of the low toxicity of TRAIL to normal cells and t...
PURPOSE Vascular endothelial growth factor (VEGF) induces angiogenesis and vascular permeability and is thought to be operative in several ocular vascular diseases. The VEGF isoforms are highly conserved among species; however, little is known about their differential biological functions in adult tissue. In the current study, the inflammatory potential of two prevalent VEGF isoform splice vari...
Smac mimetics are being developed as a new class of anticancer therapies. Because the single-agent activity of Smac mimetics is very limited, rational combinations represent a viable strategy for their clinical development. The combination of Smac mimetics with TNF-related apoptosis inducing ligand (TRAIL) may be particularly attractive because of the low toxicity of TRAIL to normal cells and t...
Blood vessels and neurons share guidance cues and cell-surface receptors to control their behaviour during embryogenesis. The transmembrane protein NRP1 (neuropilin 1) is present on both blood vessels and nerves and binds two structurally diverse ligands, the class 3 semaphorin SEMA3A and an isoform of the vascular endothelial growth factor VEGF-A termed VEGF(165) (VEGF(164) in mice). In vitro,...
Fast kinetic methods are used to measure reactions that take place in less time than required to mix the reagents manually and to measure the reaction by usual methods, like UV-visible spectrophotometry and fluorescence. The best known of them are rapid-mixing and relaxation methods, which are used for reactions with half-times in the millisecond and microsecond ranges, respectively. The picose...
The uncertainty in mean discharge from two large South American rivers (the Amazonas at Obidos, Brazil, and the Parana at Corrientes, Argentina) resulting from variation in the data used to fit rating curves at the two sites is evaluated. For the Amazonas at Obidos, where mean annual discharge over the 27-year period 19701996 was 164 200 m s'\ uncertainty arising from rating curve variability a...
The murine VEGF gene is alternatively transcribed to yield the VEGF(120), VEGF(164), and VEGF(188) isoforms, which differ in their potential to bind to heparan sulfate and neuropilin-1 and to stimulate endothelial growth. Here, their role in retinal vascular development was studied in mice selectively expressing single isoforms. VEGF(164/164) mice were normal, healthy, and had normal retinal an...
2.Merril, C.R., D. Goldman, S.A. Sedman and M.H. Ebert. 1981. Ultrasensitive stain for proteins in polyacrylamide gels shows regional variation in cerebrospinal fluid proteins. Science 211:1437-1438. 3.Sheffield, V.C., J.S. Beck, A.E. Kwitek, D.W. Sandstrom and E.M. Stone. 1993. The sensitivity of single-strand conformation polymorphism analysis for the detection of single base substitutions. G...
BACKGROUND Although the endurance shuttle walk test (ESWT) has proven to be responsive to change in exercise capacity after pulmonary rehabilitation (PR) for COPD, the minimally important difference (MID) has not yet been established. We aimed to establish the MID of the ESWT in patients with severe COPD and chronic hypercapnic respiratory failure following PR. METHODS Data were derived from ...
AMA Girsang B, Elfirae E. Development of a web-based “Perineal Care Protocol” educational model as assistance for postpartum perineal wound care at home. Family Medicine & Primary Review. 2023;25(2):160-164. doi:10.5114/fmpcr.2023.127674. APA Girsang, B., Elfirae, (2023). Review, 25(2), 160-164. https://doi.org/10.5114/fmpcr.2023.127674 Chicago Bina Melvia, and Eqlima Elfirae. 2023. "Developmen...
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