PURPOSE Triplex-forming oligonucleotides (TFO) bind to the DNA double helix in a sequence-specific manner. Therefore, TFO seem to be a suitable carrier for Auger electron emitters to damage exclusively targeted DNA sequences, e.g., in tumor cells. We studied the influence of I-125 labeled TFO with regard to cell survival and induction of DNA double-strand breaks (DSB) using TFO with different g...

CA-125 is a 220-kD cell surface glycoprotein present in over 80% of non-mucinous epithelial ovarian carcinomas and it occurs in the serum of healthy males and females at low concentrations (< 35 U/mL). Serum CA-125 concentration may also be moderately elevated in several benign conditions, such as pelvic inflammatory disease, uterine fibroids, pregnancy, spontaneous abortion with chromosomal ab...

The effect of rat spinal cord explants and cell-free nerve extract on acetylcholine receptor site density and distribution was studied using (125)I- and rhodamine-labeled alpha-bungarotoxin on L(6), a cloned rat muscle cell line. Control L(6) myotubes have a low and uniform distribution of acetylcholine receptors (20 +/- 3 sites per mum(2) in the present study). The addition of spinal cord expl...

We characterized Cl(-) conductance activated by extracellular ATP in an immortalized cell line derived from rabbit distal bright convoluted tubule (DC1). (125)I(-) efflux experiments showed that ATP increased (125)I(-) loss with an EC(50) = 3 microM. Diphenylamine-2-carboxylate (10(-3) M) and NPPB (10(-4) M) abolished the (125)I(-) efflux. Preincubation with 10 microM 1, 2-bis(2-aminophenoxy)et...

Digital printing has the potential of enabling cleaner or even dyeing cotton fabrics. However, whilst effluent-free digital and synthetic textile fabrics have seen some success, same remain elusive for The study reported in this paper aimed to optimize process parameters cationic pre-treatment with a view creating fabric that could be sustainably implemented at bulk-scale production. Thus, vari...

Nitrogen compounds added to the soil may convert nitrate and cause contamination. The distribution uniformity of in surface vs. subsurface drip irrigation systems were compared a physical model consisting transparent glass box (1.20 x 0.5 1 m) sandy loam soil, considering emitter installation depths 0 30 cm, discharge rates Q1 = 2, Q2 4, Q3 8 L/h, fertilizer levels S1 125, S2 250, S3 375 mg/L. ...

BACKGROUND Combination of the inhaled long-acting muscarinic antagonist umeclidinium (UMEC; GSK573719) with the long-acting β2-agonist vilanterol (VI) is an approved maintenance treatment for COPD in the US and EU. We compared the efficacy and safety of UMEC/VI with placebo in patients with COPD of Asian ancestry. PATIENTS AND METHODS In this 24-week, Phase III, multicenter, randomized, doubl...