Non-invasive imaging of amyloid-β in the brain, a hallmark of Alzheimer's disease, may support earlier and more accurate diagnosis of the disease. In this study, we assessed the novel single photon emission computed tomography tracer (123)I-ABC577 as a potential imaging biomarker for amyloid-β in the brain. The radio-iodinated imidazopyridine derivative (123)I-ABC577 was designed as a candidate...

OBJECTIVE The aim of this study is to establish the optimal regions of interest (ROIs) in anatomically normalized I-123 FP-CIT SPECT images for the quantification of dopamine transporter binding. METHODS The subjects comprised 16 normal controls and 14 Parkinsonian patients. All of the normal control subjects underwent I-123 FP-CIT SPECT and MRI. The SPECT device used in this study was a Tosh...

UNLABELLED Functional techniques are playing a pivotal role in the imaging of cancer today. Our aim was to compare, on a head-to-head basis, 3 functional imaging techniques in patients with histologically verified neuroendocrine tumors: somatostatin receptor scintigraphy (SRS) with (111)In-diethylenetriaminepentaacetic acid-octreotide, scintigraphy with (123)I-metaiodobenzylguanidine (MIBG), an...

UNLABELLED A simplified technique using (123)I-N-isopropyl-p-iodoamphetamine ((123)I-IMP) autoradiography (ARG) with SPECT has been proposed recently for quantifying regional cerebral blood flow (rCBF). To validate the accuracy of (123)I-IMP-ARG for quantifying regional cerebrovascular reactivity (rCVR) to acetazolamide, we compared rCVR determined using (123)I-IMP-ARG with that determined usin...

The effect of nitric oxide synthase (NOS) inhibition and endothelin-A (ETA)-receptor blockade on neural sympathetic control of vascular tone in the gastrocnemius muscle was examined in anesthetized dogs under conditions of constant flow. Muscle perfusion pressure (MPP) was measured before and after NOS inhibition (Nomega-nitro-L-arginine methyl ester; L-NAME) and ETA-receptor blockade [cyclo-(D...

“Over the Internet, no one knows you're a dog,” goes the joke. Yet, in most systems, a password submitted over the Internet gives one the same access rights as one typed at the physical console. We promote an alternate approach to authentication, in which a system fuses observations about a user into a probability (an authentication confidence) that the user is who they claim to be. Relevant ob...

International flows of high-skilled talent from developing countries to high-income OECD countries have grown in recent decades. Between 1970 and 1997, the number of foreign-born individuals in science and engineering occupations in the United States increased at three times the rate as that of natives, going from 7.6 percent in 1970 to 15 percent in 1997 (D’Costa, 2008). More recent data from ...

predicate P whenever it is possible, instead of using a catalog of theta-roles, which are difficult to justify. The use of abduction operations is limited hereto predicates already present in the core event structure. In other words, predicatesfrom the OS introduced by the core event are tried first. In this case, the OS [:at(z,y), at(z, y)] encodes the change of location that i...

In the title compound, C(12)H(15)NO(3), all C, N and O atoms lie in a mirror plane. An intramolecular C-H⋯O hydrogen bond is present.