A rice tiller is a specialized grain-bearing branch that contributes greatly to grain yield. The MONOCULM 1 (MOC1) gene is the first identified key regulator controlling rice tiller number; however, the underlying mechanism remains to be elucidated. Here we report a novel rice gene, Tillering and Dwarf 1 (TAD1), which encodes a co-activator of the anaphase-promoting complex (APC/C), a multi-sub...

In this paper, we prove that the modular curve X(11) over a field of characteristic 3 admits the Mathieu group M 11 as an automorphism group. We also examine some aspects of the geometry of the curve X(11) in characteristic 3. In particular, we show that every point of the curve is a point of inflection, the curve has 110 hyperflexes and there are no inflectional triangles and 144 inflectional ...

F. Abe,17 H. Akimoto,39 A. Akopian,31 M. G. Albrow,7 A. Amadon,5 S. R. Amendolia,27 D. Amidei,20 J. Antos,33 S. Aota,37 G. Apollinari,31 T. Arisawa,39 T. Asakawa,37 W. Ashmanskas,18 M. Atac,7 P. Azzi-Bacchetta,25 N. Bacchetta,25 S. Bagdasarov,31 M. W. Bailey,22 P. de Barbaro,30 A. Barbaro-Galtieri,18 V. E. Barnes,29 B. A. Barnett,15 M. Barone,9 G. Bauer,19 T. Baumann,11 F. Bedeschi,27 S. Behren...

Congenital Complete Heart Block (CCHB) is a rare diagnosis, with limited multicenter outcomes data. Prior reports have observed pacemaker (PM) placement in 69% of fetal diagnosed patients by age 1 and 74-96% 20. Rates PM mortality contemporary CCHB cohort not been well described. We performed retrospective study utilizing the Pediatric Health Information Systems (PHIS) database to analyze time ...

This review considers the definition of a healthy bone phenotype through the life course and the modulating effects of muscle function and nutrition. In particular, it will emphasise that optimal bone strength (and how that is regulated) is more important than simple measures of bone mass. The forces imposed on bone by muscle loading are the primary determinants of musculoskeletal health. Any f...

Although lumbar instability is considered to be responsible for the majority of chronic or recurrent backaches, the word ‘instability’ is still poorly defined. A number of different definitions exist, but as yet there are no clear and validated clinical features by which instability might be diagnosed. It is also not clear how instability as such might set up pain and disability. It is generall...

Recent studies in laboratory rodents have revealed that circadian oscillation in the physiologic functions affecting drug disposition underlies the dosing time-dependent change in pharmacokinetics. However, it is difficult to predict the circadian change in the drug pharmacokinetics in a diurnal human by using the data collected from nocturnal rodents. In this study, we used cynomolgus monkeys,...