APOBEC3 enzymes are a key source of mutagenesis in breast cancer. PI3K inhibitors currently used the treatment PIK3CA-mutated advanced However, whether specific PIK3CA mutations (muts) associated with better outcomes is unclear. We developed computational framework to screen for APOBEC3-induced within TCW context using whole-exome sequencing (WES) data from cancer cohort genome atlas (TCGA-BRCA...

7036 Background: Single agent docetaxel, 75 mg/m2 every 3 weeks given second line improves survival compared with other chemotherapeutic regimens or best supportive care in advanced NSCLC. This multicentre phase III study was initiated to compare standard 3-weekly docetaxel with weekly docetaxel as second-line therapy for advanced NSCLC. METHODS Patients (pts) with stage IIB-IV NSCLC were ran...

BACKGROUND Phrenic nerve stimulation (PNS) and high pacing thresholds (HPT) hinder biventricular stimulation in patients (pts) undergoing cardiac resynchronization therapy (CRT). A new quadripolar left ventricular (LV) lead (Quartet 1458Q, St. Jude Medical) with increased number of pacing configuration, might overcome this problem. METHODS All consecutive pts in whom a standard bipolar lead i...

Distortion product otoacoustic emissions (DPOAE), permanent threshold shifts (PTS) and outer hair cell (OHC) losses were analyzed in a population of 187 noise-exposed chinchillas to determine the predictive accuracy (sensitivity and specificity) of the DPOAE for PTS and OHC loss. Auditory evoked potentials (AEP) recorded from the inferior colliculus of the brainstem were used to estimate hearin...

The partial transmit sequences (PTS) scheme achieves an excellent peak-to-average power ratio (PAPR) reduction performance of orthogonal frequency division multiplexing (OFDM) signals at the cost of exhaustively searching all possible rotation phase combinations, resulting in high computational complexity. Several researchers have proposed using binary-coded genetic algorithms (BGA) PTS to redu...

BACKGROUND The validation of sample stability through pneumatic tube system (PTS) is essential. The objective of this study was to evaluate the effects of PTS transportation on laboratory results. METHODS Paired EDTA and SST blood samples were collected from 56 randomly selected patients. Laboratory parameters were compared between PTS group and hand-delivered group. RESULTS No statistical ...

Methods Patients (pts) from TENDER were included if baseline and wk 6 fasting insulin were measured. Glucocorticoid tapering was not permitted until wk 6. Insulin sensitivity was quantified using the homeostatic model of insulin resistance (HOMA-IR). Pts were classified as having IR if their HOMA-IR was ≥2.2 U. Change in HOMA-IR after 6 wks was assessed using paired t-test. Baseline association...

This study aimed to determine the biomechanical effect of the posterior condylar offset (PCO) and posterior tibial slope (PTS) in posterior-stabilized (PS) fixed-bearing total knee arthroplasty (TKA). We developed ±1, ±2, and ±3 mm PCO models in the posterior direction and -3°, 0°, 3°, and 6° PTS models using a previously validated FE model. The influence of changes in the PCO and PTS on the bi...

1. In contrast to the extensive documentation on diagnosis and treatment of deep venous thrombosis (DVT), information about long-term complications, like the post-thrombotic syndrome (PTS), is scarce. Most studies report on clinical examination only, whereas adequate haemodynamic investigation is lacking. Therefore 81 patients with venographically confirmed lower extremity DVT were clinically a...