نتایج جستجو برای: 102 and 09 tonha
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The polymorphism of human leukocyte antigen (HLA), which is a genetic factor that influences the progression of hemorrhagic fever with renal syndrome (HFRS) after Hantaan virus (HTNV) infection, was incompletely understood. In this case-control study, 76 HFRS patients and 370 healthy controls of the Chinese Han population were typed for the HLA-A, -B, and -DRB1 loci. The general variation at th...
Department of Experimental and Clinical Medicine, Section of Pharmacology and Neuroscience Center (G.C., A.R., F.M., G.M., D.R., E.G., S.Z., D.R., M.M., G.C.) and Department of Pharmaceutical Sciences and Biotechnology Center (R.G., S.S.), University of Ferrara, 44100 Ferrara, Italy. Department of Cardiovascular Sciences, Pharmacology and Therapeutics Group (T.A.B., J.McD., C.P.H., D.G.L.) and ...
TAS-102 significantly improves overall survival in patients with metastatic colorectal cancer. The most common adverse event of TAS-102 is bone marrow suppression, which leads to neutropenia. The incidence of neutropenia is high, and there is no known effective prevention method. Furthermore, the administration method of TAS-102 is complicated. We reported that neutropenia could be avoided by c...
Rheumatoid arthritis (RA) significantly affects quality of life. We recently cloned synoviolin, a RING-type E3 ubiquitin ligase implicated in the endoplasmic reticulum-associated degradation (ERAD) pathway. Synoviolin is highly expressed in rheumatoid synovial cells and may be involved in the pathogenesis of RA. Inhibition of synoviolin activity i...
ABSTRACT No isolated factor influences soybean development and production more than the sowing date, but responses of cultivars sown on different dates depends their sensitivity to environmental conditions. Thus, this study evaluated adaptability stability 17 genotypes in relation yield, as well grain oil protein contents a function times. The experiment was designed randomized blocks with thre...
Portal blood flow (litres/min)† 2·77 2·15 2·87 0·29 NS‡ ,0·001 NS Net portal flux (mmol/h) Glucose 258 203 242 21 0·20 ,0·001 ,0·001 Insulin flux (nmol/h)§ 9·0 3·6, 15·7 10·5 4·8, 17·5 4·6 0·01,10·2 – 0·09 0·04 NS C-peptide (nmol/h)§ 7·9 4·6, 11·4 6·6 3·4, 10·0 5·5 2·4, 8·8 – NS ,0·001 NS GLP-1 (nmol/h)§ 1·6 1·2, 2·0 1·8 1·4, 2·2 1·9 1·4, 2·3 – NS ,0·001 NS GIP (nmol/h)§ 4·4 2·1, 6·9 2·8 0·5, 5...
We compared the blood RNA transcriptome of children hospitalized with influenza A H1N1/09, respiratory syncytial virus (RSV) or bacterial infection, and healthy controls. Compared to controls, H1N1/09 patients showed increased expression of inflammatory pathway genes and reduced expression of adaptive immune pathway genes. This was validated on an independent cohort. The most significant functi...
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