Wide area networking speeds are being upgraded to 40 and 100 Gbit/s. However, applications face several challenges when trying to take advantage of these higher speeds. SARA has analysed these challenges and performed several measurements with respect to possible bottlenecks. The analysis shows that research is needed with respect to several aspects of network load balancing. SARA's performance...

New developments in the realm of skin rejuvenation such as phytotherapy are at an astounding increasing pace in the cosmeceutical market. Yet, many of these products that are classified as cosmeceuticals are tested less vigorously and do not have to be approved by the Food and Drug Administration to establish efficacy and safety. Thus, as clinicians, we must ask the question, ‘‘Is there science...

Melanoma patients treated with anti-CTLA-4 have shown a range of anti-tumor responses. In this report, we describe the response of a single patient to anti-CTLA-4, with individual lesions disappearing, others stabilizing, and others progressing. These responses can be viewed as a clear manifestation of cancer immunoediting and its three phases of elimination, equilibrium and escape, with each t...

1Bristol-Myers Squibb Company, Princeton, New Jersey, USA 2Bristol-Myers Squibb Company, Wallingford, Connecticut, USA 3Comprehensive Melanoma Research Center, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA 4Division of Gastroenterology, Cedars-Sinai Medical Center, Los Angeles, California, USA 5Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Cent...

The search for novel tumour antigens that are either uniquely expressed or over-expressed in a wide variety of tumours is still ongoing. Because of their expression in a broad spectrum of cancers and limited expression in normal tissues, cancer/testis antigens are considered to be potentially reliable targets for immunotherapy of cancer in general. The helicase antigen HAGE has been identified ...

It is well known that ocular bioavailability after topical instillation is extremely low compared with the other administration including oral administration, transdermal application, vitreous injection, and implantable delivery. The ocular bioavailability is also affected by a variety of pharmaceutical factors such as formulation viscosity and the particle size of suspension, and so on. In spi...

Two species in the genera Neoperla and Kamimuria (Plecoptera: Perlidae) from China are described as new: Kamimuria guangxia sp. n., and Neoperla mesostyla sp. n. The new species are compared to similar taxa.