PURPOSE One of the most important tools against foot-and-mouth disease, a highly contagious and variable viral disease of cloven-hoofed animals, is vaccination. However, the effectiveness of foot-and-mouth disease vaccines on slowing the spread of the disease is questionable. In contrast, high potency vaccines providing early protection may solve issues with the spread of the disease, escaping ...

Objective: Moringa oleifera Lam. is the most widely cultivated species of the monogeneric family Moringaceae and has an impressive range of medicinal uses with high nutritional value. In this study saponin was isolated from Moringa oleifera pods. Methods: Thin layer chromatography (TLC) was performed using a mobile phase of Chloroform: methanol: H2O (7:3:1) on silica gel glass plates. High perf...

background: marine natural products contain a wide range of bioactive compounds with therapeutic properties that have revealed crucial properties in the treatment of some diseases. some of these compounds have recently received considerable attention for drug discovery. in this study we examined the anti-angiogenic effect of saponin isolated from holothuria leucospilota (sea cucumber) through e...

acanthophyllum laxiusculum is one of the most widely distributed species of the genus in iran that flourishes in steppe and mountainous regions of the country. in the present study, water-soluble content of a. laxiusculum roots was extracted by boiling water and further successively purified partially by a defined solvent system. surface tension measurements revealed the ability of plant extrac...

The studies conducted on plants grown in Kashan have showed the presence of abundant valuable industrial - medicinal plants. Unforlunately, a lot of these plants are removed as weed or grazed by livestock because of Lack of inhabitants' ignorance of their using and mismanagement. - Perovskia abrotanoides is of Lamiaceae family. The natural habitat of this plant is mostly near waterways, the bed...

For studies on the lysosome-stabilizing effect of D-glucaric acid derivatives which have been found to have anti-inflammatory effect, the available and soluble enzyme activities of acid phosphatase of rat liver lysosomes were determined. Saliployed as standards. Lysosomes were incubated with drugs under specific conditions which allowed the data on the stabilizing activity of the drugs to be re...

Jiaogulan (Gynostemma pentaphyllum; GP) contained a saponin glycoside which was related to ginseng saponin. The purpose of this study was to identify the main saponin in water extract GP compared to methanol and ethanol extract. The sample was prepared by alkaline cleavage, trimethylsilyl (TMS) derivatization and gas chromatographic-mass spectrometric (GC-MS) analysis comparison with standard g...

In a previous study by Omura and Osogoe (1951), it has been shown that in acute saponin poisoning in rabbits, injury to sinusoidal walls opens the bone marrow parenchyma to the blood current and the marrow cells are depleted to a large extent. Since the mode of reaction of the reticuloendothelial (RE) cells lining the sinusoidal walls in the bone marrow and liver to saponin is still unknown, th...

Saponin OSW-1 (5e-G2; 3 beta,16 beta,17 alpha-trihydroxycholest-5-en-22-one 16-O-{O-[2-O-(4-methoxybenzoyl)-beta-D-xylopyranosyl]-(1-->3)-2-O-acetyl-alpha-arabinopyranoside}) analogues: with modified side chain (5a/d-G2), 22-deoxo-23,24,25,26,27-pentanor- (14), 22-deoxo-23-oxa- (17), glycosylated with various monosaccharides (5e-G4/G6/G8), and OSW-1 structural isomer (10) were obtained. The ana...