A promising imidazole compound was synthesized through the following route. The reaction of 5-methyl-2-phenyl-1H-imidazole-4-carbohydrazide (1) with carbon disulfide and potassium hydroxide in ethanol (80%) afforded salt (2). Refluxing (2) phenacyl bromide (3) ethanol/water (1:1) gave 2-((5-(5-methyl-2-phenyl-1H-imidazol-4-yl)-1,3,4-oxadiazol-2-yl)thio)-1-phenylethan-1-one (4) a 76% yield. stru...

About half of the drugs currently produced are chiral compounds, and about 90 % these compounds sold as racemates, consisting an equimolar mixture two enantiomers. Although they have same chemical structure, most optical isomers substances show marked differences in biological activity. It is known that presence a single asymmetric atom has become almost integral part advanced drug design. The ...