The role of the VV in the pathogenesis of atherosclerosis has been studied using animal models of atherosclerosis and human autopsy samples. Histological analyses and micro-CT studies of the pig coronary artery have revealed that inflammatory cells accumulate in the adventitia with proliferation of the VV prior to arterial wall thickening.6 In a mouse model of hypert is a generally accepted vie...

Vaccinia virus (VV) is a powerful tool for cancer treatment with the potential tumor tropism, efficient cell-to-cell spread, rapid replication in cells, and stimulation of anti-tumor immunity. It has well-defined safety profile being assessed late-stage clinical trials. However, VV utility limited by bloodstream neutralization poor penetration into tumors. These factors have often restricted it...

We have analyzed the effects of vaccinia virus (VV) on gamma interferon (IFN-gamma) signal transduction. Infection of cells with VV 1 to 2 h prior to treatment with IFN-gamma inhibits phosphorylation and nuclear translocation of Stat1 and consequently blocks accumulation of mRNAs normally induced by IFN-gamma. While phosphorylation of other proteins in the IFN-gamma pathway was not affected, ac...

The Great Observatories All-sky LIRG Survey (GOALS) combines data from NASA’s Spitzer, Chandra, Hubble and GALEX observatories, together with ground-based data into a comprehensive imaging and spectroscopic survey of over 200 low redshift (z < 0.088), Luminous Infrared Galaxies (LIRGs). The LIRGs are a complete subset of the IRAS Revised Bright Galaxy Sample (RBGS), which comprises 629 extragal...

The objective of this study was to analyze multifunctional autoprocessing repeats-in-toxin (MARTX) toxin domain organization within the aquatic species Vibrio vulnificus as well as to study the evolution of the rtxA1 gene. The species is subdivided into three biotypes that differ in host range and geographical distribution. We have found three different types (I, II, and III) of V. vulnificus M...

Ras (Rat sarcoma) protein is a central regulator of cell growth and proliferation. Mutations in the RAS gene are known to occur in human cancers and have been shown to contribute to carcinogenesis. In this study, we show that the multifunctional-autoprocessing repeats-in-toxin (MARTX) toxin-effector domain DUF5(Vv) from Vibrio vulnificus to be a site-specific endopeptidase that cleaves within t...

AIMS Biventricular pacing (BiP) is an effective treatment in systolic heart failure (HF) patients with prolonged QRS. However, approximately 35% of the patients receiving BiP are classified as non-responders. The aim of this study is to evaluate the acute effects of VV-optimization on systolic heart function. METHODS Twenty-one HF patients aged 72 (46-88) years, QRS 154 (120-190) ms, were stu...

Poxviruses, including vaccinia virus (VV) and canarypox virus (ALVAC), do not indiscriminately infect all cell types of the primary human leukocytes (PHLs) that they encounter but instead demonstrate an extremely strong bias toward infection of monocytes and monocyte lineage cells. We studied the specific molecular events that determine the VV tropism for major PHL subsets including monocytes, ...

OBJECTIVES Variable ventilation (VV) seems to improve respiratory function in acute lung injury and may be combined with positive end-expiratory pressure (PEEP) in order to protect the lungs even in healthy subjects. We hypothesized that VV in combination with moderate levels of PEEP reduce the deterioration of pulmonary function related to general anesthesia. Hence, we aimed at evaluating the ...