The effect of L-carnitine on in vivo fatty acid utilization was determined using colostrum-deprived newborn piglets fed emulsified triglycerides (TG) composed of [1-C]octanoate (tri-8:0) or [1-C]octadecanoate (tri-18:1). A soy protein–based liquid diet devoid of L-carnitine was fed piglets for 1 d to allow development of fatty acid–metabolizing enzymes and intestinal fat digestion and absorptio...

In the title compound, C(4)H(12)N(2) (2+)·2C(6)H(2)N(3)O(7) (-)·C(4)H(10)N(2), the piperazine-1,4-diium cations and piperazine mol-ecules lie on crystallographic inversion centres. In the crystal structure, inter-molecular N-H⋯O and N-H⋯N hydrogen bonds link the components to form two-dimensional layers parallel to the (001) plane. These layers are, in turn, connected by weak inter-molecular C-...

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Two isomeric partially acetylated galactocerebrosides, ß-D-galactopyranosyl (2,3,4-tri-O-acetyl)and ß-Dgalactopyranosyl (2,4,6-tri-O-acetyl)-1’(3’-O-acetyl)ceramide, were prepared from galactocerebroside and sulfatide, respectively. Their galactofuranosylation produced ß-D-galactofuranosyl-6and ß-D-galactofuranosyl-3-ß-Dgalactopyranosyl-1’ceramide, as demonstrated by 1 H and 13 C NMR spectra as...

Trichloroethylene (Tri) caused modest cytotoxicity in freshly isolated human proximal tubular (hPT) cells, as assessed by significant decreases in lactate dehydrogenase (LDH) activity after 1 h of exposure to 500 microM Tri. Oxidative metabolism of Tri by cytochrome P-450 to form chloral hydrate (CH) was only detectable in kidney microsomes from one patient out of four tested and was not detect...