Cycloadditions of azides with alkynes to form triazoles under thermal conditions (Huisgen cycloaddition) or in the presence of copper [click reaction, copper-catalyzed azide– alkyne cycloaddition (CuAAC)] are reactions of fundamental importance in organic chemistry. Triazoles can also be obtained by means of ruthenium, silver, and iridium catalysis, as well as by a zinc-mediated process. In sha...

BACKGROUND 1,2,4-Triazoles and 1,2,3-triazoles have gained significant importance in medicinal chemistry. RESULTS This study describes a green, efficient and quick solvent free click synthesis of new 1,2,3-triazole-4,5-diesters carrying a lipophilic side chain via 1,3-dipolar cycloaddition of diethylacetylene dicarboxylate with different surfactant azides. Further structural modifications of ...

We have developed an easy method for the synthesis of thirteen compounds derived from 1,2,4-triazoles through a carboxylic acid and hydrazinophthalazine reaction, with a 75-85% yield mediated by the use of agents such as 1-ethyl-3-(3 ́-dimethylaminopropyl)carbodiimide hydrochloride and 1-hydroxybenzotriazole. The operational simplicity of this method and the good yield of products make it valuab...

2-Arylhydrazono-3-oxobutanenitriles 2 was reacted with hydroxylamine hydrochloride to yield amidooxime 3. This was cyclized into the corresponding oxadiazole 4 on refluxing in acetic anhydride. When refluxed in DMF in presence of piperidine, the corresponding 1,2,3-triazoleamine 5 was formed. The latter was acylated to 6 by addition of acetic anhydride while treatment of 5 with malononitrile ga...

compound n2, n3, n7, n8, 1, 4, 5, 6, 9, 10-decaphenyltetradecahydrodipyrazino [2, 3-b: 2, 3-e] pyrazine-2, 3, 7, 8-tetraamine (4) was prepared by condensation of 1, 1′, 2, 2′-tetrakis (phenylamino) ethane (1d) and glyoxal in etoh or i-proh. also, reaction of 1d with glyoxal in equimolare in etoh resulted 5,6-bis (ethoxy)-n2, n3, 1, 4-tetraphenylhexahydro-2, 3-pyrazinediamine (5). the natures of...