B7-H1 (CD274) is a T-cell coinhibitory molecule that is also often induced on human carcinoma cells, where its expression has been implicated in immune escape. Under inflammatory conditions, B7-H1 is also inducible in normal epithelial cells but little is known about its involvement in conversion of normal cells to tumor cells. Here, we show that skin-specific expression of B7-H1 accelerates in...

Therapies that target the PD-1/B7-H1 axis have revolutionized cancer treatment, yet precise knowledge of how this pathway provides benefit continues to evolve. Here, we report a novel role for the immune checkpoint ligand B7-H1 in the accumulation of tissue-resident memory CD8+ T-cells (TRM). After intracranial infection, Theiler's murine encephalomyelitis virus (TMEV) generates TRM that are ma...

Let H1 be an n × n invertible Hermitian matrix, and let U(H1) be the group of n × n H1-unitary matrices, i.e., matrices A satisfying A H1A = H1. Suppose H2 is an m × m invertible Hermitian matrix. We show that a linear transformation φ : Mn → Mm satisfies φ(U(H1)) ⊆ U(H2) if and only if there exist invertible matrices S ∈ Mm, U, V ∈ U(H2) such that SH2S = [(Ia ⊕−Ib)⊗H1]⊕ [(Ic ⊕−Id)⊗ (H−1 1 )], ...

We propose a method for treating the Dirichlet boundary conditions in the framework of the Generalized Finite Element Method (GFEM). We use approximate Dirichlet boundary conditions as in [12] and polynomial approximations of the boundary. Our sequence of GFEM-spaces considered, Sμ, μ = 1, 2, . . . is such that Sμ 6 ⊂ H1 0 (Ω), and hence it does not conform to one of the basic FEM conditions. L...

Although self-reactive T-cell precursors can be eliminated upon recognition of self-antigen presented in the thymus, this central tolerance process is often incomplete, and additional mechanisms are required to prevent autoimmunity. Recent studies indicates that the interaction between B7-H1 and its receptor PD-1 on activated T cells plays an important role in the inhibition of T-cell responses...

Although self-reactive T-cell precursors can be eliminated upon recognition of self-antigen presented in the thymus, this central tolerance process is often incomplete, and additional mechanisms are required to prevent autoimmunity. Recent studies indicates that the interaction between B7-H1 and its receptor PD-1 on activated T cells plays an important role in the inhibition of T-cell responses...

BACKGROUND AND AIM B7-H1, a co-inhibitory molecule of the B7 family, is found aberrantly expressed in ovarian cancer cells and infiltrating macrophage/dendritic-like cells, and plays a critical role in immune evasion by ovarian cancer. IL-12, an inducer of Th1 cell development, exerts immunomodulatory effects on ovarian cancer. However, whether IL-12 regulates B7-H1 expression in human ovarian ...

We consider the existence of at least one positive solution of the problem –D0+u(t) = f (t,u(t)), 0 < t < 1, under the circumstances that u(0) = 0, u(1) = H1(φ(u)) + ∫ E H2(s,u(s))ds, where 1 < α < 2, D α 0+ is the Riemann-Liouville fractional derivative, and u(1) = H1(φ(u)) + ∫ E H2(s,u(s))ds represents a nonlinear nonlocal boundary condition. By imposing some relatively mild structural condit...