BACKGROUND Bortezomib is a proteasome inhibitor currently studied in clinical trials of childhood cancers. So far, no side effects on bone growth have been reported in treated children. However, bortezomib was recently found to induce apoptosis in growth plate chondrocytes and impair linear bone growth in treated mice. We hypothesize that [Gly(14)]-humanin (HNG), a 24-amino acid synthetic antia...

abstract the present study is attempted to present the minimum required meteorological parameters for reference evapotranspiration estimation at hamedan region of iran from 1997 to 1998. employing pierson test, six meteorological parameters which are used by penman-montieth fao-56 method including maximum and minimum air temperature, maximum and minimum relative humidity, wind speed and daily s...

The following method was used to apply the topology of current study evapotranspiration ETo, net irrigation demand, schedules, and total effective rain fall different crop models: using Food Agriculture Organization's (FAO) CROPWAT 8.0 standard software CLIMWAT 2.0 tool FAO-56 Penman-Monteith approach examine variable ETo. Due high temperatures in summer with an annual mean 6.33 mm/day, topolog...

The effects of four different antihypertensive drugs (the Ca(2+)-channel blocker felodipine, the beta-blocker metoprolol, the angiotensin converting enzyme inhibitor ramipril, and the alpha-blocking agent doxazosin) on microalbuminuria and renal hemodynamics were evaluated in a double-blind, crossover study in 17 patients (10 women, seven men, aged 39 +/- 14 years) with mild-to-moderate essenti...

Few thorough comparisons of the systemic effects of inhaled corticosteroids in children are available. The aim of this study was to compare the effect of budesonide and fluticasone propionate on short-term lower leg growth. Fluticasone propionate, budesonide and placebo were administered for 2 weeks in a randomized, double-blind, double-dummy, cross-over design. Twenty four children aged 6-12 y...

We adapted telemetry and sequence analysis employed in humans to mice and measured heart rate variability and the spontaneous baroreflex sensitivity in angiotensin II type 2 (AT2) receptor-deleted (AT2 -/-) and wild-type (AT2 +/+) mice with either deoxycorticosterone acetate (DOCA)-salt hypertension or N(omega)-nitro-L-arginine methylester hydrochloride (L-NAME) hypertension. Mean arterial pres...