We hypothesize that skin cancer emerges from a combination of mutations and tissue disruption. characterize clonal dynamics transcriptional signatures during carcinogenesis using lineage tracing. For 3 months, we UV-irradiated fluorophore expressing K14Cre-ERT2 Confetti mice. Clone volumes were computed 3-D digitized confocal z-stacks. scRNAseq was used to compare UV-exposed (EXP) epidermis, no...

IntroductionClosed reduction and intramedullary nailing is the preferred surgical intervention for femoral shaft fractures. Open involves opening fracture site performed in various circumstances. Comparative studies of approaches have conflicting results. We sought to compare outcomes complications open closed fractures.Materials methodsFollowing Preferred Reporting Items Systematic Reviews Met...

Abstract Background Cystic fibrosis (CF) is a genetic disease that affects the respiratory, digestive, and reproductive systems. One of issues associated with CF oxidative stress, which an imbalance between production reactive oxygen species (ROS) ability body to neutralize them. Peroxynitrite, member ROS, very noxious molecule formed from reaction nitric oxide (NO) superoxide can damage cellul...