For a long time necrosis was thought to be an uncontrolled process but evidences recently have revealed that necrosis can also occur in a regulated manner. Necroptosis, a type of programmed necrosis is defined as a death receptor-initiated process under caspase-compromised conditions. The process requires the kinase activity of receptor-interacting protein kinase 1 and 3 (RIPK1 and RIPK3) and m...

We screened a series of new epoxysuccinyl peptides for the development of a lysosomal cathepsin L-specific inhibitor. Among the compounds tested, (2S,3S)-oxirane-2,3-dicarboxylic acid 2-[((S)-1-benzylcarbamoyl-2-phenyl-ethyl)-amide] 3-{[2-(4-hydroxy-phenyl)-ethyl]-amide} (compound CAA0225) was the most potent inhibitor of cathepsin L. CAA0225 inhibited rat liver cathepsin L with IC50 values of ...

Particulate air pollution, specifically the fine particle fraction (PM2.5), has been associated with increased cardiopulmonary morbidity and mortality in general population studies. Occupational exposure to fine particulate matter can exceed ambient levels by a large factor. Due to increased interest in the health effects of particulate matter, many particle sampling methods have been developed...

A contact interaction analysis is presented to search for new phenomena beyond the Standard Model in deep inelastic ep → e hadrons scattering. The data are collected with the H1 detector at HERA and correspond to integrated luminosities of 0.909 pb and 2.947 pb for electron and positron beams, respectively. The differential cross sections dσ/dQ are measured in the Q range between 160 GeV and 20...

Merhamet doyumu kişinin merhametli eylemlerde bulunmaktan dolayı elde ettiği memnuniyet halidir. Bu çalışmanın amacı yetişkinlerin merhamet doyumlarını belirlemeye yönelik Doyumu ölçeğinin geliştirilmesidir. Ölçeğin psikometrik özelliklerinin belirlenebilmesi için 504 yetişkinden veri toplanmıştır. Yapılan açımlayıcı faktör analizi sonucunda 12 madde tek bir altında toplanmış ve bu faktörlü yap...