© 2017 The Author(s). Published by Taylor & Francis on behalf of the Nordic Orthopedic Federation. This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (https://creativecommons.org/licenses/by-nc/3.0) DOI 10.1080/17453674.2017.1407058 1. Calculate the score as recommended Patient-reported outcome measures (PROMs) are becoming more...

Purpose To evaluate ocular comfort of lifitegrast ophthalmic solution 5.0% among patients with dry eye disease (DED) in the OPUS-3 trial. Methods OPUS-3 was a multicenter, randomized, double-masked, placebo-controlled study. Adults with DED and recent artificial tear use were randomized 1:1 (lifitegrast:placebo) to ophthalmic drops twice daily for 84 days. On days 0 (baseline), 14, 42, and 84...

The sampling strategies in many randomized matrix algorithms are, either explicitly or implicitly, controlled by statistical quantities called leverage scores. We present four bounds for the sensitivity of leverage scores as well as an upper bound for the principal angles between two matrices. These bounds are expressed by considering two real m×n matrices of full column rank, A and B. Our boun...

The only approved clot-busting medical treatment in ischemic stroke, intravenous thrombolysis (IVT), is not without complications. One of the major reasons for withholding the therapy remains fear of symptomatic intracranial hemorrhage (sICH), which can worsen patients’ outcomes. The number needed for IVT to cause fatal sICH is 36.5, and to cause any worsening of outcome (≥1 grade on modified R...