The crystal structure of pimecrolimus Form B has been solved and refined using synchrotron X-ray powder diffraction data optimized density functional techniques. Pimecrolimus crystallizes in the space group P 2 1 (#4) with a = 15.28864(7), b 13.31111(4), c 10.95529(5) Å, β 96.1542(3)°, V 2216.649(9) Å 3 , Z 2. Although there are an intramolecular six-ring hydrogen bond some larger chain ring pa...

Type 1 interferons (IFN-1) are major drivers of disease activity in systemic (SLE) and cutaneous lupus erythematosus (CLE). Plasmacytoid dendritic cells (pDCs) the producers IFN-1 during viral infection. pDCs reduced circulation SLE have recently been shown to an exhausted phenotype, suggesting that pathogenic were located end organs. We performed imaging mass cytometry treatment naïve CLE skin...