Clostridium difficile is the commonest cause of antibiotic-associated diarrhoea, with the hospitalized elderly being at particular risk. The organism makes a crystalline surface protein layer (S-layer), encoded by the slpA gene, the product of which is cleaved to give two mature peptides which associate to form the layer. The larger peptide (high molecular weight; HMW), derived from the C-termi...

A series of diaryl- and fluorenone-based analogs of the lead compound UA-62784 [4-(5-(4-methoxyphenyl)oxazol-2-yl)-9H-fluoren-9-one] was synthesized with the intention of improving upon the selective cytotoxicity of UA-62784 against human pancreatic cancer cell lines with a deletion of the tumor suppressor gene deleted in pancreas cancer locus 4 (DPC-4, SMAD-4). Over 80 analogs were synthesized...

The high accessibility of the skin and the presence of immunocompetent cells in the epidermis makes this surface an attractive route for needle-free administration of vaccines. However, the lining of the skin by the stratum corneum is a major obstacle to vaccine delivery. In this study we examined the effect of skin barrier disruption on the immune responses to the cross-reacting material CRM(1...

Abstract Background Glucose-6-phosphate dehydrogenase (G6PD) deficiency, the most common enzymopathy in humans, is prevalent tropical and subtropical areas where malaria endemic. Anti-malarial drugs, such as primaquine tafenoquine, can cause haemolysis G6PD-deficient individuals. Hence, G6PD testing recommended before radical treatment against vivax malaria. Phenotypic assays have been widely u...

——————————————— For Correspondence: Vanaja Paul, F–1, Varalakshmi Castle, 3, Akbarabad II Street, Kodambakkam, Chennai – 600 024, India. Lecturer in Zoology, Bharathiar University, Coimbatore – 641 046, India. E-mail: [email protected] Professor of Pharmacology (Retd), University of Madras, Chennai, India. EFFECT OF VITAMIN D ON CHRONIC BEHAVIORAL AND DENTAL TOXICITIES OF SODIUM FLUORIDE ...