Bacterial adherence to the acquired dental pellicle, important in dental caries (caries), is mediated by receptor-adhesins such as salivary agglutinin binding to Streptococcus mutans antigen I/II (I/II). Ten selected I/II epitopes were chosen to determine their reactivity to human salivary IgA. Previous studies suggested that a specific HLA biomarker group (HLA-DRB1*04) may have differential in...

The pharmacological inhibition of general transcriptional regulators has the potential to block growth through targeting multiple tumorigenic signalling pathways simultaneously. Here, using an innovative cell-based screen, we identify a structurally unique small molecule (named JIB-04) that specifically inhibits the activity of the Jumonji family of histone demethylases in vitro, in cancer cell...

Isoflavones have been suggested to have hypolipidemic effects. As these compounds undergo complex metabolism in the body, the biological actions of isoflavone metabolites are largely unknown. We studied the hypolipidemic effects of two isoflavone metabolites initially identified in the human urine, cis-tetrahydrodaidzein (NV-04) and transtetrahydrodaidzein (NV-05) in apolipoprotein(E)-deficient...

OBJECTIVE Human leukocyte antigen (HLA) DRB1*04:36 is a low-frequency HLA-DRB1 allele. The aim here is to report the ethnicity of DRB1*04:36 and its associated HLA haplotypes among Taiwanese individuals. MATERIALS AND METHODS A sequence-based typing method was employed to confirm this low incidence allele. Polymerase chain reaction was performed to amplify exons 2 and 3 of the HLA-A and HLA-B...

We obtain the energy distribution of a Schwarzschild black hole in a magnetic universe in the Tolman prescription. PACS: 04. 20.-q; 04. 70.-s