Introduction Cryopyrin-associated periodic syndrome (CAPS), clinically characterized by neutrophil-rich urticarial rash, is associated with missense mutations in NLRP3. NLRP3 is a pattern recognition receptor in the cytoplasm of cells and structurally related to plant resistance proteins, which detect pathogenor danger-associated signals, leading to programmed cell death and hyper response at t...

The purine metabolic enzymes adenosine deaminase (ADA) and purine nucleoside phosphorylase (PNP) are important in lymphocyte differentiation, and genetic deficiencies of either enzyme have been associated with hereditary immunodeficiency states. Both ADA and PNP activity were measured in null cell-enriched and T cell-enriched peripheral blood lymphocytes from 16 patients with the acquired immun...

Circadian changes in the susceptibility of adult individuals of three cricket species: field cricket (Gryllus campestris), house cricket (Acheta domesticus), and tropical house cricket (Gryllodes sigillatus) to insecticides belonging to the group of synthetic pyrethroids (Bulldock 025 EC) and oxadiazine (Steward 30 WG) were tested in 2007 and 2008. The assessment included the intoxication of su...

Risk factors for nontraumatic amputations are well-documented in literature. However, the risk of progression from transmetatarsal amputation (TMA) to more proximal is not well understood despite subsequent loss functionality. In this study, we investigated that were associated with limb among patients peripheral arterial disease (PAD). We analyzed our institutional database a single tertiary c...

Immunotherapy has drastically improved the survival prospect for advanced melanoma. Unfortunately, these treatments often come with cutaneous side effects which may cause patient to discontinue or delay therapy. To understand mechanism of immunotoxicity in relation clinical presentation, we characterized symptom clusters by and histologic morphology, severity rating, transcriptional analyses pa...