Background & Aims: In spite of frequent produce and use of magnetic nanoparticles in biological fields, there are few studies on their side effects, especially under in-vivo conditions. Method: In this research, the effect of the single-dose intraperitoneal injection of DMSA (dimercaptosuccinic acid) coated magnetic iron oxide nanoparticles (Fe3O4) in different doses (50, 100, 200 and 300 mg/kg...

ansemia, was caused by the barbiturates she was taking. Both amylobarbitone sodium and quinalbarbitone sodium, the constituents of tuinal, are closely related chemically to primidone, sodium phenytoin, and phenobarbitone, but a megaloblastic anaemia has not previously been described in association --ith their use. The doses that this patient was taking (gr. 18-20 for 6-8 months) were, however, ...

Objective(s): Iranian researchers have enriched conventional engine oil with nanoparticles at the Institute of Petroleum Research and hope that this product can replace conventional engine oil due to the improved effects of copper nanoparticles on oils. the purpose of this study was to investigate the pathological effect of engine oil enriched with copper nanoparticles on the rat.Methods:...

Abstract This study focuses on the microstructure characteristics and mechanical properties of unreinforced reinforced ceramic materials titanium diboride (TiB 2 ) graphite (Gr). Aluminium hybrid metal matrix nanocomposites with varying weight percentage nano TiB (0-12.5 wt. %) Gr (4wt via electromagnetic stir casting process to produce samples. Identification phases analysis are performed thro...

introduction: in the kindling-induced seizure model, low and repeated electrical or chemical stimulations, can elevate the neural network excitability and induce epileptiform seizures. opioid receptors are widely distributed in different areas of the brain. on the other hand, morphine has paradoxical effects and induces elevation or alleviation of the pain sensation and excitability, at differe...

Introduction: Several studies indicate that estrogen use increase performance on some tests of cognition especially in postmenopausal women. These steroids have many side effects, thus, other estrogenic agents with fewer side effects are needed to develop alternative treatment strategies. The main objection of this study was to evaluate the effects of different doses of dietary soy meals (with ...

The present study investigates the antioxidant potential of the ethyl acetate fraction of the aerial parts Eclipta alba L. Hassk (EAEA) which was widely used as hepatoprotective plant. EAEA was orally administered at doses of 50, 100 and 200 mg/kg for 7 days in male Charles Foster rats. The extent of hepatoprotective potential of E . alba was studied by assessing the biochemical para...

ONYX-015 is an adenovirus that lacks the E1B-55K gene product for p53 degradation. Thus, ONYX-015 was conceived as an oncolytic virus that would selectively replicate in p53-defective tumor cells. Here we show that loss of E1B-55K leads to the induction, but not the activation, of p53 in ONYX-015-infected primary cells. We use a novel adenovirus mutant, ONYX-053, to demonstrate that loss of E1B...

BACKGROUND We investigated whether cytolytic melittin peptides could inhibit HIV-1 infectivity when carried in a nanoparticle construct that might be used as a topical vaginal virucide. Free melittin and melittin-loaded nanoparticles were prepared and compared for cytotoxicity and their ability to inhibit infectivity by CXCR4 and CCR5 tropic HIV-1 strains. METHODS TZM-bl reporter cells expres...

BACKGROUND It is urgent to find alternative agents due to increasing failure rate of Helicobacter pylori (H. pylori) eradication. The study surveyed the long-term effect of silver nanoparticles (AgNP) on H. pylori based on Mongolian gerbil's model. MATERIALS AND METHODS Fifty gerbils were randomly allocated to six groups (A-F). Group (Gr) A: the gerbils were fed with broth; Gr B and D: the ge...