In the course of screening for novel anticancer compounds, B1 [N-(2-(dimethylamino)ethyl)-2-aminothiazonaphthalimide], a novel amonafide analogue, was generated as a new anticancer candidate. In the present study, B1 displayed stronger antitumor effects than amonafide in HL60 cells. We further examined whether B1 overcomes the resistance conferred by Bcl-2, as overcoming the resistance conferre...

Signaling through the semaphorin 4D (Sema4D) receptor plexin-B1 is modulated by its interaction with tyrosine kinases ErbB-2 and Met. In cells expressing the plexin-B1-ErbB-2 receptor complex, ligand stimulation results in the activation of small GTPase RhoA and stimulation of cellular migration. By contrast, in cells expressing plexin-B1 and Met, ligand stimulation results in an association wi...

I a comparative study on normal and B1-receptor deficient (B1-KO) mice, Pesquero et al. (1) provide evidence in this issue of PNAS in favor of crucial roles played by the kinin B1 receptor in toxic shock, inflammation, and nociception. B1 receptors are generally silent or absent in healthy states and are induced or activated by pathological challenges. When they are absent, as in B1-KO mice, ti...

An interesting method for B1 mapping based on the Bloch-Siegert (BLS) shift was recently presented (1,2) for gradient echo (FLASH) and Spin Echo (SE) sequences. This method uses off-resonant pulses before signal acquisition to encode the B1 information into the signal phase. Fast B1 mapping is possible since the repetition time has only minor influence on the quality of the phase information. I...

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where x ∈ R is represents the variables, c ∈ R defines the objective function, and A ∈ Rm×n and b ∈ R define the constraints. The above form is fairly general; one can model various types of constraints in this form. For example, a constraint 〈a1, x〉 ≥ b1 can be written as 〈−a1, x〉 ≤ −b1. Or, a constraint 〈a1, x〉 = b1 can be written as 〈a1, x〉 ≤ b1 and 〈−a1, x〉 ≤ −b1. The objective function can...

Cyclin genes and their products are important regulatory participants in the eukaryotic cell cycle. It is well established that cyclin B1 protein forms a complex with cyclin-dependent kinase 1 (CDK1), which, when activated, initiates mitosis. We have previously established that cyclin B1 gene expression is posttranscriptionally regulated in regenerating rat liver after 70% partial hepatectomy (...