the anxiolytic effect of the flower of echium. amoenum was shown in several experimental studies in mice. the present study was aimed to determine whether tolerance develops to anxiolytic action of e. amoenum in mice. nmri male mice were injected intraperitoneal with hydroalcoholic extract (12.5, 25 and 50 mg/kg) or saline once each day (8 am) for period of 7 days and then tested on light/dark ...

    The aim of this study was to assess the efficacy and tolerability of the aqueous extract of Echium amoenum in combination with SSRIs in patients with General Anxiety Disorder (GAD). The study was an 8-week double-blind randomized clinical trial. Thirty-seven adult outpatients who met the DSM-IV-TR criteria for GAD based on the structured clinical interview participated in the trial. In this...

Putative activity of hydroalcoholic and aqueous infusion extracts of Echium amoenum L. was investigated in mice using the rotarod model of motor coordination and the elevated plus maze model of anxiety. The extracts were administered intraperitonealy (i.p.) once, one hour before performing the tests. Preliminary phytochemical study of the plant, with standard procedures, showed that it contains...

anxiety disorders are amongst the most popular diseases which interfere with normal life. benzodiazepines are used as a first line of treatment, but difficulties with pharmacotherapy of anxiety disorders such as dependence and low response rate, encourage researchers to find new approaches. from the past, the role of medicinal plants have been a subject of intense interest. in this respect, cit...

Background & Aim:Iranian ox-tongue (Echium amoenum Fisch. & Mey.) is an endemic Iranian medicinal plant belongs to Boraginaceae family. The violet-blue petals of this plant have been used in traditional medicine. Drying is one of the most critical and fundamental operations in the post-harvest processing of medicinal plants. Experimental: This re...

Background & Aim:Iranian ox-tongue (Echium amoenum Fisch. & Mey.) is an endemic Iranian medicinal plant belongs to Boraginaceae family. The violet-blue petals of this plant have been used in traditional medicine. Drying is one of the most critical and fundamental operations in the post-harvest processing of medicinal plants. Experimental: This re...