Objective(s): To investigate the effect of miR-103 on the angiogenesis of ischemic stroke rats via targeting vascular endothelial growth factor (VEGF) at the molecular level. Materials and Methods: Rat models had received the middle cerebral artery occlusion (MCAO) or sham operation before grouping, and cell models of oxygen-glucose deprivation (OGD) were performed. FITC-dextran, matrigel, and ...

Background and Aims: Chronic lymphocytic leukemia (CLL) is the most common adult human leukemia. MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression. Research has shown that in CLL, microRNAs can have function as oncogenes or tumor suppressors. Some studies demonstrated that the expression of microRNA-93 (miR-93) and microRNA-330 (miR-330) have been changed in several can...

Identifying immunocompromised women who are at risk of developing cervical cancer remains a challenge for clinicians. In an effort to identify the role HIV in carcinogenesis, this study evaluated levels normally downregulated oncomirs (miR-21, miR-146a, miR-155, miR-182, and miR-200c) upregulated tumor suppressors (miR-let-7b, miR-125b, miR-143, miR-145, p53 expression) associated with serum li...

One of the mechanisms for development autoimmune diseases is changes in epigenetic regulation, root causes which have not yet been established. At same time, data on role transposons as sources long noncoding ribonucleic acids (RNA) and microRNAs involved immune pathology accumulated. In evolution, transposable elements become basis emergence V(D)J recombination regulation HLA genes. Pathologic...

Breast cancer is a leading cause of related death among women worldwide and it complex disease characterized by its heterogeneity. The heterogenous characteristic the breast responsible for aggressiveness treatment resistance. stem cells (BCSCs) are population with increased propensity proliferation, differentiation, migration, invasion mammosphere formation resistance to treatment. They have a...

Objective(s): MicroRNAs (miRs) are a class of small non-coding RNAs which are associated with tumor growth and progression. In the present study, we assessed the expression of selected miRs in malignant, benign, and adjacent normal breast tissues. Materials and Methods: The expression of miR-1297, miR-3191-5P, miR-4435, and miR-4465 were...

Objective(s): MicroRNAs (miRNAs) are considered as powerful, post-transcriptional regulators of gene expression in hepatocellular carcinoma cells (HCC). However, the function of miR-92a is still unclear in HCC. Materials and Methods: Expression of miR-92a in human HCC cell lines was evaluated using qRT-PCR. MTT assay and transwell assay were used to examine the function of miR-92a in HepG2 and ...