Despite significant advances have been achieved in the genetic characterization of sporadic colorectal cancer (sCRC), the precise genetic events leading to the development of distant metastasis remain poorly understood. Thus, accurate prediction of metastatic disease in newly-diagnosed sCRC patients remains a challenge. Here, we evaluated the specific genes and molecular pathways associated wit...

Aberrant expression of the cell cycle kinase inhibitors, p16 and p21, has been associated with poor prognosis in a number of human malignancies. These proteins may also be involved in the development and progression of gastroenteropancreatic neuroendocrine tumors (GEP-NETs). The present study aimed to investigate protein levels of p16 and p21 in GEP-NETs and to evaluate their clinical significa...

RATIONALE The radiotherapy (RT) responses of gastroenteropancreatic (GEP)-origin neuroendocrine tumors remain unclear. We report cases of favorable response after localized RT of GEP-origin neuroendocrine carcinomas (GEP-NECs). PATIENT CONCERNS 1. An 82-year-old male presented with a lower esophageal mass. Positron emission tomography computed tomography (PET-CT) scan showed a lower esophagea...

In this study, the efficiency of neuro-fuzzy inference system (ANFIS) and genetic expression programming (GEP) in predicting the transfer length of prestressing strands in prestressed concrete beams was investigated. Many models suggested for the transfer length of prestressing strands usually consider one or two parameters and do not provide consistent accurate prediction. The alternative appr...

An increased association between neuroendocrine tumors of the gastrointestinal tract and pancreas (GEP-NET) and other second primary malignancies has been suggested. We determined whether there is indeed an increased risk for second primary malignancies in GEP-NET patients compared with an age- and sex-matched control group of patients with identical malignancies. The series comprised 243 men a...

Gene expression programming (GEP) is frequently used to create intelligent dispatching rules for job-shop scheduling. The proper selection of the terminal set a critical factor success GEP. However, there are various job features and machine that can be included in sets capture different characteristics state. Moreover, importance varies greatly between scenarios. irrelevant redundant may lead ...

UNLABELLED BACKGROUND Gastroenteropancreatic neuroendocrine neoplasm (GEP-NEN) is the most common type of neuroendocrine tumors accounting for 65-75% of neuroendocrine neoplasms (NENs). Given the fact that there are few studies on GEP-NENs among Chinese patients, we performed a retrospective study in South China. METHODS Totally 178 patients with GEP-NENs treated at the First Affiliated Ho...

Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) are rare and heterogeneous group of tumors presenting as localised or metastatic disease and in a subset with distinct clinical syndromes. Treatment is aimed at controlling the functional syndrome, eradicating the tumor, and/or preventing further tumor growth. Surgery is the treatment of choice in removing the primary tumor and/or reduc...

This study formulates the effects of two different historical data types on electrical energy consumption of ASEAN-5 counties. On this basis, optimized GEP (gene expression programming) is applied to precisely formulate the relationships between historical data and electricity consumption. The optimized GEP is a more recent extension of GEP with high probability of finding closed-form solution ...

The gastroenteropancreatic (GEP) neuroendocrine tumors (NETs) are rare tumors and include all tumors arising from the gastrointestinal (GI) or pancreatic neuroendocrine cells. They can occur anywhere in the GI tract with the small intestine, pancreas and rectum being the common GI sites. Because of nonspecific symptoms they are difficult to diagnose and diagnosis is often delayed by years. Adva...