Two cardioacceleratory peptides from the corpora cardiaca of Periplaneta americana have been purified by gel filtration and reversed-phase liquid chromatography, Based on analysis of the intact factors and their chymotryptic fragments, we have assigned the primary structure of these octapeptides as pGlu-Val-Asn-Phe-Ser-Pro-Asn-Trp-NH2, designated periplanetin CC-1, and pGlu-Leu-Thr-Phe-Thr-Pro-...

Immunomodulatory drugs (IMiDs) are potent inhibitors of TNFand IL-1 and elevators of IL-10 production in LPS-stimulated human PBMC. They are currently in clinical trials for various diseases, including multiple myeloma, myelodysplastic syndrome, and melanoma. In the present study, we have investigated the eVects of thalidomide, CC-5013 and CC-4047 on the expression of COX-2 by stimulated PBMC. ...

Building a computationally creative system is a challenging undertaking. While such systems are beginning to proliferate, and a good number of them have been reasonably well-documented, it may seem, especially to newcomers to the field, that each system is a bespoke design that bears little chance of revealing any general knowledge about CC system building. This paper seeks to dispel this conce...

In this article, we tackle the problem of compiling cc(X) languages 9, 13] where X is an admissible constraint domain. The diiculty of this task consists in one) representing and optimising diierent domains X and two) providing an parallel and extensible execution model. A simple way to meet these demands is to provide a minimal parallel (and distributable) kernel language expressive enough to ...