Compared with the sequence and expression similarity, miRNA functional similarity is so important for biology researches and many applications such as miRNA clustering, miRNA function prediction, miRNA synergism identification and disease miRNA prioritization. However, the existing methods always utilized the predicted miRNA target which has high false positive and false negative to calculate t...

Regulation of miRNA (microRNA) biogenesis shapes the profiles of miRNAs in the living cell, contributing to cell identity and function. Importantly, aberrant miRNA levels have been linked to a variety of human pathological states. In recent years, a number of proteins have been shown to regulate the miRNA biogenesis at the level of Drosha and Dicer cleavage. A large proportion of these factors ...

INTRODUCTION Hepatitis B virus (HBV) constitutes an important risk factor for cirrhosis and hepatocellular carcinoma (HCC). The link between circulating microRNAs and HBV has been previously reported, although not as a marker of liver disease progression in chronic hepatitis B (CHB). The aim of this study was to characterize miRNA expression profiles between CHB with and without cirrhosis or HC...

Abstract Objectives Hepatocellular carcinoma (HCC) is one of the most common causes cancer-related deaths, due to high morbidity, a low early diagnosis rate, and poor prognosis. It essential explore competitive endogenous RNA (ceRNA) arrays for prognosis HCC. Methods The original gene expression profiles differentially expressed lncRNA, miRNA mRNA in HCC were downloaded from TCGA database. Diff...

RNA interference (RNAi) is one of the primary machineries involved in regulation gene expression using small double-stranded (dsRNA) eukaryotic cells. MicroRNA (miRNA) a class non-coding RNAs, regulating through canonical and non-canonical ways. Previous studies have shown that miRNA coding sequences make up 1% human genome currently 1917 miRNAs are displayed miRBase database. Expression levels...

Wound healing is a complex and well-orchestrated process to keep our skin intact. This delicate repair often gets disrupted in patients with underlying causes. However, the effective wound therapy lacking due limited knowledge of related molecular pathogenesis. In this study, we performed paired small RNA (miRNA) long (circular mRNA) sequencing human tissue samples, including matched acute woun...

miRGator is an integrated database of microRNA (miRNA)-associated gene expression, target prediction, disease association and genomic annotation, which aims to facilitate functional investigation of miRNAs. The recent version of miRGator v2.0 contains information about (i) human miRNA expression profiles under various experimental conditions, (ii) paired expression profiles of both mRNAs and mi...

While a growing body of evidence implicates regulatory miRNA modules in various aspects of human disease and development, insights into specific miRNA function remain limited. Here, we present an innovative approach to elucidate tissue-specific miRNA functions that goes beyond miRNA target prediction and expression correlation. This approach is based on a multi-level integration of correspondin...