Numerous early events in anthrax lethal toxin (LT)-mediated cell killing have been described, including uptake of LT and MAPKK cleavage. However, critical downstream events in LT killing remain to be identified. In this study we present evidence that LT causes mitochondrial dysfunction in murine J774A.1 macrophages, as indicated by a continuous drop in both mitochondrial membrane potential and ...

AIM Although alcoholic liver disease (ALD) is an accepted indication for liver transplantation (LT), there are several controversial issues. The aim of this study is to examine the applicability of the 6-month abstinence rule prior to LT and to evaluate the results in living donor LT for patients with ALD. METHODS A retrospective study of 102 patients with ALD referred for LT was performed. C...

Although early allograft dysfunction (EAD) negatively impacts survival from the first months following liver transplantation (LT), direct-acting antiviral agents (DAAs) have revolutionized hepatitis C virus (HCV) therapy. We investigated the EAD definition best predicting 90-day graft loss and identified EAD risk factors in HCV-positive recipients. From November 2002 to June 2016, 603 HCV-posit...

Although salvage liver transplantation (LT) has been widely adopted as a treatment for recurrent hepatocellular carcinoma(HCC), candidate selection criteria have not been established. This single-center study aimed to identify risk factors associated with HCC recurrence and survival following salvage LT. The study included 74 patients treated with salvage LT between October 2001 and February 20...

s | 91 Methods: Forty-five right-handed patients with PD who met the diagnostic criteria in Structured Clinical Interview for DSM-V and twenty-two healthy control were examined by means of MRI at 3 Tesla. We used the FreeSurfer software package to create a three-dimensional model of the cortical surface for estimating the cortical thickness. In order to test the effect of the gene polymorphism ...

background: our study compares the efficacy of the combined contraceptive vaginal ring to oral contraceptive pills (ocps) for hypothalamic-pituitary-ovarian (hpo) axis suppression in egg donor in vitro fertilization (ivf) cycles. methods: our retrospective cohort study includes patients from the center for assisted reproduction (care) in bedford, texas undergoing ivf cycles as egg donors from j...

Rats immunized with a semipurified preparation of the Escherichia coli heat-stable (ST) enterotoxin conjugated with a protein carrier were protected against challenge with semipurified or purified ST and viable organisms of multiple heterologous serotypes that produce only ST (LT-/ST+), but they were not protected against heal-labile (LT) toxin or viable strains which produce LT either alone (L...

Let {Lt ; (x, t) ∈ R1 ×R1 +} denote the local time of Brownian motion. Our main result is to show that for each fixed t ∫ (L t − Lt )3 dx− 12h ∫ (L t − Lt )Lt dx h2 L =⇒ √ 192 (∫ (Lt ) 3 dx )1/2 η as h → 0, where η is a normal random variable with mean zero and variance one that is independent of Lt . This generalizes our previous result for the second moment. We also explain why our approach w...

INTRODUCTION Critically ill cirrhosis patients awaiting liver transplantation (LT) often receive prioritization for organ allocation. Identification of patients most likely to benefit is essential. The purpose of this study was to examine whether the Sequential Organ Failure Assessment (SOFA) score can predict 90-day mortality in critically ill recipients of LT and whether it can predict receip...